Publication Name	World Journal of Clinical Cases
Manuscript ID	81517
Country	China

Received	2022-11-17 10:17
Peer-Review Started	2022-11-17 10:18
To Make the First Decision
Return for Revision	2023-01-12 01:14
Revised	2023-02-01 16:34
Second Decision	2023-03-06 03:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-03-06 08:39
Articles in Press	2023-03-06 08:39
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-02-27 14:17
Typeset the Manuscript	2023-03-15 23:19
Publish the Manuscript Online	2023-03-30 13:19

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Andrology
Manuscript Type	Case Report
Article Title	Diagnosis and treatment of primary seminoma of the prostate: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Zhi-Lie Cao, Bi-Jun Lian, Wei-Ying Chen, Xu-Dong Fang, Hang-Yang Jin, Ke Zhang and Xiao-Ping Qi
ORCID	Author(s) ORCID Number Bi-Jun Lian http://orcid.org/0000-0001-9387-2120 Ke Zhang http://orcid.org/0000-0001-8139-1418 Xiao-Ping Qi http://orcid.org/0000-0003-1543-0727
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81472861 The Key Project of Zhejiang Province Science and Technology Plan, China 2014C03048-1 Hangzhou Municipal Commission of Health and Family Planning Science and Technology Program B20210355
Corresponding Author	Xiao-Ping Qi, MM, Professor, Department of Urology, The 903rd PLA Hospital, Hangzhou Medical College, No. 40 Jichang Road, Hangzhou 310004, Zhejiang Province, China. qxplmd@163.com
Key Words	Prostatic neoplasms; Seminoma; Germ cell and embryonic neoplasms; Diagnosis; Case report
Core Tip	Primary seminoma of the prostate (PSP) is a rare type of extragonadal germ cell tumour that is easily misdiagnosed, owing to the lack of specific clinical features. To the best of our knowledge, there have been only 13 cases of PSP reported in the literature, and there is a lack of systemic research on the condition. Through this case report and literature review, we suggested that PSP should be considered in patients younger than 60 years with an enlarged prostate invading the bladder neck. This symptom occurs in 92.9% of PSP patients, and has a high sensitivity but low specificity for diagnosis. However, additional prostate biopsies may aid diagnosis, and histopathological studies are the most effective diagnostic technique. The prognoses of PSP patients are often good. While cisplatin-based chemotherapy remains to be the first-line treatment, surgery or radiotherapy may also be important options, depending on each patient’s response to chemotherapy and the location of the residual tumour.
Publish Date	2023-03-30 13:19
Citation	Cao ZL, Lian BJ, Chen WY, Fang XD, Jin HY, Zhang K, Qi XP. Diagnosis and treatment of primary seminoma of the prostate: A case report and review of literature. World J Clin Cases 2023; 11(10): 2267-2275
URL	https://www.wjgnet.com/2307-8960/full/v11/i10/2267.htm
DOI	https://dx.doi.org/10.12998/wjcc.v11.i10.2267

Full Article (PDF)	WJCC-11-2267.pdf
Full Article (Word)	WJCC-11-2267.docx
CARE Checklist–2016	81517-CARE-Checklist–2016-revision.pdf
Manuscript File	81517_Auto_Edited-JRF-Wang TQ-JLW.docx
Answering Reviewers	81517-Answering reviewers.pdf
Audio Core Tip	81517-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	81517-Conflict-of-interest statement.pdf
Copyright License Agreement	81517-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	81517-Grant application form(s).pdf
Signed Consent for Treatment Form(s) or Document(s)	81517-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	81517-Language certificate.pdf
Peer-review Report	81517-Peer-review(s).pdf
Scientific Misconduct Check	81517-Bing-Fan JR-2.png
Scientific Editor Work List	81517-Scientific editor work list.pdf
CrossCheck Report	81517-CrossCheck report.pdf
CrossCheck Report	81517-CrossCheck.png