Publication Name	World Journal of Gastroenterology
Manuscript ID	81519
Country	South Korea

Received	2022-11-18 14:59
Peer-Review Started	2022-11-18 15:03
To Make the First Decision
Return for Revision	2022-11-30 06:57
Revised	2022-12-08 15:18
Second Decision	2023-01-30 03:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-01-30 18:21
Articles in Press	2023-01-30 18:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-01-31 07:26
Publish the Manuscript Online	2023-02-10 09:15

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Implications of recent neoadjuvant clinical trials on the future practice of radiotherapy in locally advanced rectal cancer
Manuscript Source	Invited Manuscript
All Author List	Min Kyu Kang
ORCID	Author(s) ORCID Number Min Kyu Kang http://orcid.org/0000-0002-7962-7054
Funding Agency and Grant Number
Corresponding Author	Min Kyu Kang, MD, PhD, Associate Professor, Department of Radiation Oncology, Kyungpook National University Chilgok Hospital, 807 Hoguk-ro, Buk-gu, Daegu 40414, South Korea. mkkang@knu.ac.kr
Key Words	Rectal cancer; Neoadjuvant therapy; Radiotherapy; Total neoadjuvant treatment; Immunotherapy
Core Tip	In locally advanced rectal cancer (LARC), recent randomized controlled trials have demonstrated the benefits of total neoadjuvant treatment (TNT) in terms of oncologic outcomes and organ preservation. The results of clinical trials of immunotherapy suggest the possibility of pelvic radiotherapy in combination with immunotherapy for LARC. However, the radiotherapy details used in clinical trials have not changed significantly. This study reviewed recent neoadjuvant clinical trials evaluating TNT and immunotherapy from a radiation oncologist’s perspective to guide future radiotherapy for LARC.
Publish Date	2023-02-10 09:15
Citation	Kang MK. Implications of recent neoadjuvant clinical trials on the future practice of radiotherapy in locally advanced rectal cancer. World J Gastroenterol 2023; 29(6): 1011-1025
URL	https://www.wjgnet.com/1007-9327/full/v29/i6/1011.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i6.1011

Full Article (PDF)	WJG-29-1011.pdf
Full Article (Word)	WJG-29-1011.docx
Manuscript File	81519_Auto_Edited-LM.docx
Answering Reviewers	81519-Answering reviewers.pdf
Audio Core Tip	81519-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	81519-Conflict-of-interest statement.pdf
Copyright License Agreement	81519-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	81519-Language certificate.pdf
Supplementary Material	81519-Supplementary material.pdf
Peer-review Report	81519-Peer-review(s).pdf
Scientific Misconduct Check	81519-Bing-Fan JR-2.png
Scientific Editor Work List	81519-Scientific editor work list.pdf