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Articles Published Processes
3/28/2023 12:59:29 PM | Browse: 224 | Download: 523
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Received |
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2022-11-19 07:14 |
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Peer-Review Started |
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2022-11-19 07:17 |
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To Make the First Decision |
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Return for Revision |
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2022-12-10 08:49 |
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Revised |
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2023-01-12 08:20 |
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Second Decision |
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2023-03-06 03:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-03-14 17:59 |
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Articles in Press |
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2023-03-14 17:59 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-02-22 15:32 |
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Typeset the Manuscript |
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2023-03-20 09:01 |
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Publish the Manuscript Online |
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2023-03-28 12:59 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
New uses for an old remedy: Digoxin as a potential treatment for steatohepatitis and other disorders
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Fatima Jamshed, Farzaneh Dashti, Xinshou Ouyang, Wajahat Z Mehal and Bubu A Banini |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NIH UO1 (to Mehal WZ) |
5U01AA026962-02 |
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| Corresponding Author |
Bubu A Banini, MD, PhD, Assistant Professor, Section of Digestive Diseases, Yale School of Medicine, 40 Temple St, Suite 1A, New Haven, CT 06510, United States. bubu.banini@yale.edu |
| Key Words |
Digoxin; Cardiac glycosides; Oxidative stress; Nonalcoholic steatohepatitis; Alcohol-associated steatohepatitis; Sterile inflammation |
| Core Tip |
Digoxin has been used primarily as a cardiac drug for treatment of arrhythmias and heart failure. Preclinical work supports the repurposing of digoxin as therapy for non-cardiac conditions, including alcohol-associated steatohepatitis, nonalcoholic steatohepatitis, obesity and metabolic disorders, autoimmune and inflammatory conditions, malignancy, and viral infections, among others. Here, we provide an overview of findings to date on the potential clinical applications of digoxin and mechanisms of action in steatohepatitis and other non-cardiac disorders. We discuss evidence on the differential action of digoxin at high vs low concentrations and identify areas of further research necessary to harness its promising multifunctional use. |
| Publish Date |
2023-03-28 12:59 |
| Citation |
Jamshed F, Dashti F, Ouyang X, Mehal WZ, Banini BA. New uses for an old remedy: Digoxin as a potential treatment for steatohepatitis and other disorders. World J Gastroenterol 2023; 29(12): 1824-1837 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i12/1824.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i12.1824 |
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