Publication Name	World Journal of Gastroenterology
Manuscript ID	81680
Country	Portugal

Received	2022-11-19 17:58
Peer-Review Started	2022-11-19 17:59
First Decision by Editorial Office Director	2022-12-10 08:33
Return for Revision	2022-12-10 08:33
Revised	2022-12-18 21:15
Publication Fee Transferred
Second Decision by Editor	2023-02-10 03:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2023-02-15 20:33
Articles in Press	2023-02-15 20:33
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-02-23 05:20
Publish the Manuscript Online	2023-02-28 11:21

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Early-onset colorectal cancer: A review of current knowledge
Manuscript Source	Invited Manuscript
All Author List	Margarida R Saraiva, Isadora Rosa and Isabel Claro
ORCID	Author(s) ORCID Number Margarida R Saraiva http://orcid.org/0000-0002-6750-1112 Isadora Rosa http://orcid.org/0000-0002-2953-5987 Isabel Claro http://orcid.org/0000-0002-1860-6161
Funding Agency and Grant Number
Corresponding Author	Isadora Rosa, PhD, Medical Assistant, Department of Gastroenterology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Rua Prof Lima Bastos, Lisboa 1099-023, Portugal. isarosa@ipolisboa.min-saude.pt
Key Words	Colorectal cancer; Early-onset; Adenocarcinoma; Hereditary; Birth-cohort effect; Risk factors
Core Tip	The incidence of early-onset colorectal cancer (EO-CRC) has been surprisingly increasing worldwide and it has become a public health issue. Its clinical, genetic, molecular and histological characteristics suggest that this may be a distinct entity, with a more aggressive behaviour. However, both genetic and environmental risk factors seem to contribute to this observed epidemiological shift in CRC incidence. More evidence is needed in order to clarify EO-CRC aetiology and to develop screening and management strategies.
Publish Date	2023-02-28 11:21
Citation	Saraiva MR, Rosa I, Claro I. Early-onset colorectal cancer: A review of current knowledge. World J Gastroenterol 2023; 29(8): 1289-1303
URL	https://www.wjgnet.com/1007-9327/full/v29/i8/1289.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i8.1289

Full Article (PDF)	WJG-29-1289.pdf
Full Article (Word)	WJG-29-1289.docx
Manuscript File	81680_Auto_Edited-LM.docx
Answering Reviewers	81680-Answering reviewers.pdf
Audio Core Tip	81680-Audio core tip.mp4
Conflict-of-Interest Disclosure Form	81680-Conflict-of-interest statement.pdf
Copyright License Agreement	81680-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	81680-Language certificate.pdf
Peer-review Report	81680-Peer-review(s).pdf
Scientific Misconduct Check	81680-Bing-Wang JJ-2.png
Scientific Editor Work List	81680-Scientific editor work list.pdf
CrossCheck Report	81680-CrossCheck report.pdf