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Articles Published Processes
5/7/2023 7:47:34 AM | Browse: 153 | Download: 581
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Received |
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2022-11-19 22:20 |
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Peer-Review Started |
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2022-11-19 22:21 |
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To Make the First Decision |
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Return for Revision |
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2023-02-01 23:08 |
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Revised |
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2023-03-12 15:44 |
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Second Decision |
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2023-04-10 03:19 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-04-10 22:11 |
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Articles in Press |
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2023-04-10 22:11 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-04-02 18:44 |
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Typeset the Manuscript |
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2023-04-21 03:21 |
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Publish the Manuscript Online |
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2023-05-07 07:47 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Lafoensia pacari alleviates intestinal damage by modulating cyclooxygenase-2: In silico and in vivo evaluation in a colitis model
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Gabrielle Caroline Peiter, Thayene Kamyli Moesch Queiroz, Edson Luiz Michalkiewicz Jr, Raphael Henrique Chappuis, Jennefer Sousa Luz, Luiz Henrique Casagrande Piovezani, Cleison Ferreira Silva, Matheus Nozomi Tsutumi, Augusto Fernandes Chaves, Rafael Messias Luiz, Cinthia Façanha Wendel, Ana Carla Zarpelon Schutz and Kádima Nayara Teixeira |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Kádima Nayara Teixeira, PhD, Professor, Campus Toledo, Universidade Federal do Paraná, Max Planck 3796, Toledo 85.919-899, Paraná, Brazil. kadimateixeira@ufpr.br |
| Key Words |
Antinociceptive activity; Anti-inflammatory activity; Cyclooxygenase-2; Flavonoids; Inflammatory bowel disease; Lafoensia pacari |
| Core Tip |
Keto-alcoholic extracts derived from the leaves and bark of Lafoensia pacari (L. pacari) demonstrate significant analgesic/antinociceptive activity in a murine acetic acid-induced pain model of colitis. These results can likely be extrapolated to humans, as the identities and structures of mouse and human cyclooxygenase-2 (COX-2) are similar. Furthermore, mouse and human COX-2 interacted in a similar fashion with L. pacari extract flavonoids when tested in silico. Extracts from both the leaves and bark of L. pacari were found to improve inflammation and pain symptoms in mice with acetic acid-induced acute colitis. |
| Publish Date |
2023-05-07 07:47 |
| Citation |
Peiter GC, Moesch Queiroz TK, Michalkiewicz Jr EL, Chappuis RH, Luz JS, Casagrande Piovezani LH, Ferreira Silva C, Nozomi Tsutumi M, Fernandes Chaves A, Luiz RM, Façanha Wendel C, Zarpelon-Schutz AC, Teixeira KN. Lafoensia pacari alleviates intestinal damage by modulating cyclooxygenase-2: In silico and in vivo evaluation in a colitis model. World J Gastroenterol 2023; 29(17): 2628-2641 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i17/2628.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i17.2628 |
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