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Articles Published Processes
3/7/2023 4:31:44 PM | Browse: 242 | Download: 457
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Received |
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2022-11-21 01:12 |
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Peer-Review Started |
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2022-11-21 01:14 |
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To Make the First Decision |
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Return for Revision |
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2022-12-10 07:07 |
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Revised |
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2023-01-05 01:29 |
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Second Decision |
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2023-02-16 03:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-02-22 23:22 |
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Articles in Press |
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2023-02-22 23:22 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-02-27 13:21 |
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Publish the Manuscript Online |
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2023-03-07 16:31 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Thiopurines are an independent risk factor for active tuberculosis in inflammatory bowel disease patients
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Flora Maria Lorenzo Fortes, Raquel Rocha and Genoile Oliveira Santana |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Raquel Rocha, DSc, Adjunct Associate Professor, Ciência da Nutrição, Universidade Federal da Bahia, Av Araujo Pinho, Salvador 40110160, Brazil. raquelrocha2@yahoo.com.br |
| Key Words |
Tuberculosis; Inflammatory bowel disease; Thiopurines; Therapy; Risk |
| Core Tip |
Inflammatory bowel disease (IBD) patients recommended for anti-tumor necrosis factor (anti-TNF) therapy need to be tested for latent tuberculosis (TB) prior to treatment. Azathioprine monotherapy is also an independent risk factor for active TB in patients with IBD. However, the recommendations of the Brazilian Public Health Guideline for Tuberculosis Prevention do not include patients who are receiving immunosuppressive therapy in the risk group for screening for latent TB. We evaluated 301 patients with IBD, and the use of azathioprine treatment increased the risk by 6.87-fold compared to patients without this treatment. The use of anti-TNF therapy had a 10.34-fold increased risk of TB, and the combination of both increased the risk by 17.81-fold. |
| Publish Date |
2023-03-07 16:31 |
| Citation |
Fortes FML, Rocha R, Santana GO. Thiopurines are an independent risk factor for active tuberculosis in inflammatory bowel disease patients. World J Gastroenterol 2023; 29(9): 1536-1538 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i9/1536.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i9.1536 |
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