| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Tongxinluo promotes endothelium-dependent arteriogenesis to attenuate diabetic peripheral arterial disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jiao-Jiao Gu, Yun-Long Hou, Yi-Hui Yan, Jie Li, Ya-Ru Wei, Kun Ma, Xiao-Qi Wang, Jie-Han Zhang, Dan-Dong Wang, Cui-Ru Li, Dong-Qi Li, Ling-Ling Sun and Huai-Lin Gao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Hebei Province Natural Science Foundation |
H2019106062 |
| Key R&D Plan of Hebei Provincial Department of Science and Technology |
223777155D |
| Research Project of Hebei Provincial Administration of Traditional Chinese Medicine |
2023179 |
|
| Corresponding Author |
Huai-Lin Gao, PhD, Doctor, Doctor, Professor, Graduate School, Hebei University of Chinese Medicine, No.326 Xinshinan 11 Road, Qiaoxi District, Shijiazhuang 050090, Hebei Province, China. gaohuailin@126.com |
| Key Words |
Diabetic peripheral arterial disease; Arteriogenesis; Endothelial cell; Inflammation; Pyroptosis |
| Core Tip |
Peripheral arterial disease (PAD) has become one of the leading causes of disability and death in diabetic patients. Restoring blood supply to the hindlimbs, especially by promoting arteriogenesis, is currently the most effective strategy, in which endothelial cells play an important role. The present study demonstrated the role of TXL in promoting arteriogenesis in the treatment of diabetic PAD, and the mechanism may be related to the inhibition of endothelial cell pyroptosis, restoration of endothelial cell function, and promotion of endothelial-smooth muscle cell interaction. |
| Publish Date |
2023-03-15 15:41 |
| Citation |
<p>Gu JJ, Hou YL, Yan YH, Li J, Wei YR, Ma K, Wang XQ, Zhang JH, Wang DD, Li CR, Li DQ, Sun LL, Gao HL. Tongxinluo promotes endothelium-dependent arteriogenesis to attenuate diabetic peripheral arterial disease. <i>World J Diabetes</i> 2024; In press</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v14/i3/234.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i3.234 |
