| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Bone marrow mesenchymal stem cell-derived exosomal microRNAs target PI3K/Akt signaling pathway to promote the activation of fibroblasts
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Fang-Qi Li, Wen-Bo Chen, Zhi-Wen Luo, Yi-Sheng Chen, Ya-Ying Sun, Xiao-Ping Su, Jun-Ming Sun and Shi-Yi Chen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Sanming Project of Medicine in Shenzhen |
SZSM201612078 |
| Health Shanghai Initiative Special Fund (Medical-Sports Integration, Creating a New Model of Exercise for Health) |
JKSHZX-2022-02 |
|
| Corresponding Author |
Shi-Yi Chen, Doctor, MD, PhD, Academic Editor, Academic Fellow, Chairman, Department of Sports Medicine, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, Jing’an District, Shanghai 200040, China. cshiyi@163.com |
| Key Words |
Exosome; MicroRNA; Fibroblast; Mesenchymal stem cell; Tendon-bone healing |
| Core Tip |
Exosomes derived from bone marrow mesenchymal stem cells (BMSCs) can activate fibroblasts and promote tendon-bone healing via the contained microRNAs (miRNAs). Supported by bioinformatics tools, this study identified two BMSC-derived exosomal miRNAs, has-miR-144-3p and has-miR-23b-3p, were overlapped in three GSE datasets. Bioinformatic analysis revealed that both miRNAs regulated the PI3K/Akt signaling pathway by targeting phosphatase and tensin homolog (PTEN). Experiments in vitro confirmed that interfering with PTEN can affect the phosphorylation of Akt and thus the activation of fibroblasts. These results suggested a potential mechanism by which BMSC-derived exosomes promote tendon-bone healing. |
| Publish Date |
2023-04-26 08:16 |
| Citation |
Li FQ, Chen WB, Luo ZW, Chen YS, Sun YY, Su XP, Sun JM, Chen SY. Bone marrow mesenchymal stem cell-derived exosomal microRNAs target PI3K/Akt signaling pathway to promote the activation of fibroblasts. World J Stem Cells 2023; 15(4): 248-267 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i4/248.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i4.248 |
