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Articles Published Processes
4/18/2023 11:30:26 AM | Browse: 188 | Download: 384
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Received |
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2022-11-25 09:40 |
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Peer-Review Started |
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2022-11-25 09:41 |
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To Make the First Decision |
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Return for Revision |
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2022-12-12 21:17 |
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Revised |
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2023-01-19 10:34 |
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Second Decision |
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2023-03-21 03:07 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-03-21 07:24 |
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Articles in Press |
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2023-03-21 07:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-04-13 06:26 |
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Publish the Manuscript Online |
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2023-04-18 11:30 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Minireviews |
| Article Title |
Kynurenine pathway of tryptophan metabolism in pathophysiology and therapy of major depressive disorder
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Abdulla A-B Badawy, Shazia Dawood and Samina Bano |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Abdulla A-B Badawy, BPharm, PhD, Professor Emerita, Formerly School of Health Sciences, Cardiff Metropolitan University, Western Avenue, Cardiff CF5 2YB, United Kingdom. badawyabdulla@yahoo.com |
| Key Words |
Major depressive disorder; Indoleamine 2,3-dioxygenase; Kynurenine monooxygenase; Proinflammatory cytokines; Serotonin deficiency; Tryptophan 2,3-dioxygenase |
| Core Tip |
Antidepressant drugs inhibit the activity of liver tryptophan 2,3-dioxygenase (TDO) activity and bind specifically to the enzyme, but not to indoleamine 2,3-dioxygenase (IDO). IDO induction is not a major event in the pathophysiology of major depressive disorder (MDD), but may be masked and overridden by upregulation of kynurenine monooxygenase (KMO), the gateway to production of modulators of immune and neuronal functions. The pathophysiology of MDD may be underpinned by both the serotonin deficiency and glutamatergic activation mediated respectively by TDO induction and N-methyl-D-aspartate receptor activation. Inhibition of TDO and KMO should be the focus of MDD pharmacotherapy. |
| Publish Date |
2023-04-18 11:30 |
| Citation |
Badawy AAB, Dawood S, Bano S. Kynurenine pathway of tryptophan metabolism in pathophysiology and therapy of major depressive disorder. World J Psychiatry 2023; 13(4): 141-148 |
| URL |
https://www.wjgnet.com/2220-3206/full/v13/i4/141.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v13.i4.141 |
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