| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Circ_0003356 suppresses gastric cancer growth through targeting the miR-668-3p/SOCS3 axis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei-Dong Li, Hai-Tao Wang, Yue-Ming Huang, Bo-Hao Cheng, Li-Jun Xiang, Xin-Hao Zhou, Qing-Yan Deng, Zhi-Gang Guo, Zhi-Feng Yang, Zhi-Fen Guan and Yao Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Zhongshan Social Public Welfare and Basic Research Project |
200421093453685 |
|
| Corresponding Author |
Yao Wang, MD, Professor, Department of Gastrointestinal Surgery, Zhongshan City People’s Hospital, No. 2 Sunwen East Road, Zhongshan 528403, Guangdong Province, China. wangyao8065@163.com |
| Key Words |
Epithelial-mesenchymal transition; Circ_0003356; Gastric cancer; Invasion; Proliferation; Migration |
| Core Tip |
We observed the low level of circ_0003356 expression in gastric cancer (GC) tissues and cells. Circ_0003356 expression was positively related to GC patient prognosis. Exogenous circ_0003356 overexpression and/or miR-668-3p suppression enhanced apoptosis in GC cells and suppressed GC cell proliferation, migration, invasion, and epithelial to mesenchy-mal transition. The overexpression of circ_0003356 also prevented tumor growth in mice. At the mechansistic level, circ_0003356 was found to interact with the miR-668-3p/SOCS3 axis to impair GC development. Together, we reveal new and important molecular details highlighting circ_0003356 as a novel cancer target. |
| Publish Date |
2023-05-12 09:13 |
| Citation |
Li WD, Wang HT, Huang YM, Cheng BH, Xiang LJ, Zhou XH, Deng QY, Guo ZG, Yang ZF, Guan ZF, Wang Y. Circ_0003356 suppresses gastric cancer growth through targeting the miR-668-3p/SOCS3 axis. World J Gastrointest Oncol 2023; 15(5): 787-809 |
| URL |
https://www.wjgnet.com/1948-5204/full/v15/i5/787.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i5.787 |
