| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Susceptibility patterns and virulence genotypes of Helicobacter pylori affecting eradication therapy outcomes among Egyptian patients with gastroduodenal diseases
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ahmed Morad Asaad, Gasser El-Azab, Eman Abdelsameea, Osama Elbahr, Ahmed Kamal, Mohamed Abdel-Samiee, Ahmed Abdelfattah, Heba Abdallah, Doha Maher, Ahmed El-Refaie, Samar Ebrahim Ghanem, Shamshul Ansari and Samah Mohammed Awad |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Shamshul Ansari, MSc, PhD, Assistant Professor, Department of Health Sciences, Higher Colleges of Technology, Abu Dhabi Women's College, Hazza Bin Zayed Street, Al Dhafrah - Abu Dhabi, Abu Dhabi 25026, United Arab Emirates. shamshulansari483@yahoo.com |
| Key Words |
Helicobacter pylori; Eradication therapy; Virulence; Clarithromycin resistance; cagA gene; vacA gene |
| Core Tip |
In this study, 72 patients with Helicobacter pylori infections were investigated. Half of the Helicobacter pylori strains had the cagA gene, and more than half of the strains were resistant to antibiotics except tetracycline and clarithromycin (CLR). However, CLR and tetracycline were effective at higher doses to achieve effective eradication by the CLR-based therapy. Most importantly, this study demonstrated that an alternative therapeutic regimen should be adopted to achieve effective infection eradication in Egypt. |
| Publish Date |
2023-05-16 07:16 |
| Citation |
Asaad AM, El-Azab G, Abdelsameea E, Elbahr O, Kamal A, Abdel-Samiee M, Abdelfattah A, Abdallah H, Maher D, El-Refaie A, Ghanem SE, Ansari S, Awad SM. Susceptibility patterns and virulence genotypes of Helicobacter pylori affecting eradication therapy outcomes among Egyptian patients with gastroduodenal diseases. World J Gastroenterol 2023; 29(19): 2950-2960 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i19/2950.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i19.2950 |
