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Articles Published Processes
3/27/2023 2:19:30 PM | Browse: 280 | Download: 645
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Received |
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2022-12-12 09:53 |
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Peer-Review Started |
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2022-12-12 09:53 |
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To Make the First Decision |
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Return for Revision |
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2023-01-05 08:49 |
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Revised |
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2023-01-17 08:15 |
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Second Decision |
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2023-02-16 03:49 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-02-16 19:06 |
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Articles in Press |
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2023-02-16 19:06 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-02-17 09:35 |
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Publish the Manuscript Online |
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2023-03-27 14:19 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Differential expression and significance of 5-hydroxymethylcytosine modification in hepatitis B virus carriers and patients with liver cirrhosis and liver cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yue-Cui Li, Wei-Yue Hu, Cheng-Hang Li, Li-Li Zhang, Xiang-Wei Xu, Jin Li and Hong-Xia Luo |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Planning Project of Zhejiang Province |
LGF20H160001 |
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| Corresponding Author |
Yue-Cui Li, MBChB, Chief Physician, Department of Infectious Diseases, The First People’s Hospital of Yongkang, No. 599 Jinshan West Road, Yongkang, Jinhua 321300, Zhejiang Province, China. liyuecui02@yeah.net |
| Key Words |
Hepatitis B surface antigen; 5-hydroxymethylcytosine; Hepatocellular carcinoma; Liver cancer; DNA sequencing; Differentially expressed genes |
| Core Tip |
Major signaling pathways involved in differentially expressed genes are biliary secretion and insulin secretion. Abnormal secretion of bile and insulin in tumor cells may promote or symbolize the occurrence and development of liver cancer. SLC2A2 and PCK1 are the central nodes of the differential genes, which may be most closely related to the occurrence of liver cancer. FABP1, APOC3, SI, KRT20, SLC5A1, SLC10A2, RBP2, and AKR1B10 may be key genes in the protein regulatory network, and these genes may play regulatory roles after modification by 5-hydroxymethylcytosine (5hmC). Therefore, we suggest that the difference in 5hmC modification levels is related to the occurrence and progression of liver cancer. |
| Publish Date |
2023-03-27 14:19 |
| Citation |
Li YC, Hu WY, Li CH, Zhang LL, Xu XW, Li J, Luo HX. Differential expression and significance of 5-hydroxymethylcytosine modification in hepatitis B virus carriers and patients with liver cirrhosis and liver cancer. World J Gastrointest Surg 2023; 15(3): 346-361 |
| URL |
https://www.wjgnet.com/1948-9366/full/v15/i3/346.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v15.i3.346 |
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