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8/22/2014 3:56:00 PM | Browse: 591 | Download: 432
Publication Name World Journal of Clinical Cases
Manuscript ID 8219
Country/Territory United States
Received
2013-12-22 11:44
Peer-Review Started
2013-12-22 21:20
To Make the First Decision
2014-03-12 17:09
Return for Revision
2014-03-22 21:26
Revised
2014-03-23 05:50
Second Decision
2014-05-14 16:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-05-14 16:38
Articles in Press
2014-05-23 09:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-06-13 14:05
Publish the Manuscript Online
2014-06-20 19:16
ISSN 2307-8960 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Minireviews
Article Title Therapeutic strategies for targeting the ovarian tumor stroma
Manuscript Source Invited Manuscript
All Author List Song Yi Ko and Honami Naora
Funding Agency and Grant Number
Funding Agency Grant Number
Cancer and Prevention Research Institute of Texas grant RP120390 (HN)
United States National Institutes of Health CA141078 (HN)
Corresponding Author Honami Naora, PhD, Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 108, Houston, TX 77030, United States. hnaora@mdanderson.org
Key Words Ovarian cancer; Tumor stroma; Endothelial cells; Fibroblasts; Macrophages; Targeted therapy
Core Tip Despite advances in clinical management, advanced-stage ovarian cancer is still rarely cured by conventional chemotherapy. Substantial efforts have been directed to developing new therapies that target ovarian cancer cells. However, recent studies have revealed important roles of a variety of stromal cells in driving the aggressive behavior of ovarian cancer. Here, we discuss: (1) the significance of three major types of stromal cells in the progression of ovarian cancer; (2) how receptor/ligand-mediated interactions between ovarian cancer cells and stromal cells serve as focal points for therapeutic intervention; and (3) key examples of new-generation agents that target stromal cells.
Publish Date 2014-06-20 19:16
Citation Ko SY, Naora H. Therapeutic strategies for targeting the ovarian tumor stroma. World J Clin Cases 2014; 2(6): 194-200
URL http://www.wjgnet.com/2307-8960/full/v2/i6/194.htm
DOI http://dx.doi.org/10.12998/wjcc.v2.i6.194
Full Article (PDF) WJCC-2-194.pdf
Full Article (Word) WJCC-2-194.doc
Manuscript File 8219-Review.docx
Answering Reviewers 8219-Answering reviewers.pdf
Copyright License Agreement 8219-Copyright assignment.pdf
Peer-review Report 8219-Peer review(s).pdf
Scientific Editor Work List 8219-Scientific editor work list.pdf