Publication Name	World Journal of Clinical Cases
Manuscript ID	8219
Country	United States

Received	2013-12-22 11:44
Peer-Review Started	2013-12-22 21:20
To Make the First Decision	2014-03-12 17:09
Return for Revision	2014-03-22 21:26
Revised	2014-03-23 05:50
Second Decision	2014-05-14 16:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-14 16:38
Articles in Press	2014-05-23 09:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-13 14:05
Publish the Manuscript Online	2014-06-20 19:16

ISSN	2307-8960 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Minireviews
Article Title	Therapeutic strategies for targeting the ovarian tumor stroma
Manuscript Source	Invited Manuscript
All Author List	Song Yi Ko and Honami Naora
Funding Agency and Grant Number	Funding Agency Grant Number Cancer and Prevention Research Institute of Texas grant RP120390 (HN) United States National Institutes of Health CA141078 (HN)
Corresponding Author	Honami Naora, PhD, Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 108, Houston, TX 77030, United States. hnaora@mdanderson.org
Key Words	Ovarian cancer; Tumor stroma; Endothelial cells; Fibroblasts; Macrophages; Targeted therapy
Core Tip	Despite advances in clinical management, advanced-stage ovarian cancer is still rarely cured by conventional chemotherapy. Substantial efforts have been directed to developing new therapies that target ovarian cancer cells. However, recent studies have revealed important roles of a variety of stromal cells in driving the aggressive behavior of ovarian cancer. Here, we discuss: (1) the significance of three major types of stromal cells in the progression of ovarian cancer; (2) how receptor/ligand-mediated interactions between ovarian cancer cells and stromal cells serve as focal points for therapeutic intervention; and (3) key examples of new-generation agents that target stromal cells.
Publish Date	2014-06-20 19:16
Citation	Ko SY, Naora H. Therapeutic strategies for targeting the ovarian tumor stroma. World J Clin Cases 2014; 2(6): 194-200
URL	http://www.wjgnet.com/2307-8960/full/v2/i6/194.htm
DOI	http://dx.doi.org/10.12998/wjcc.v2.i6.194

Full Article (PDF)	WJCC-2-194.pdf
Full Article (Word)	WJCC-2-194.doc
Manuscript File	8219-Review.docx
Answering Reviewers	8219-Answering reviewers.pdf
Copyright License Agreement	8219-Copyright assignment.pdf
Peer-review Report	8219-Peer review(s).pdf
Scientific Editor Work List	8219-Scientific editor work list.pdf