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Articles Published Processes
4/26/2023 8:16:12 AM | Browse: 219 | Download: 613
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Received |
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2022-12-19 07:33 |
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Peer-Review Started |
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2022-12-19 07:35 |
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To Make the First Decision |
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Return for Revision |
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2023-01-06 17:55 |
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Revised |
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2023-01-18 07:17 |
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Second Decision |
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2023-03-06 03:19 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-03-21 07:36 |
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Articles in Press |
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2023-03-21 07:36 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-04-18 04:18 |
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Publish the Manuscript Online |
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2023-04-26 08:16 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Clinical application prospects and transformation value of dental follicle stem cells in oral and neurological diseases
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Chao Yang, Xin-Ya Du and Wen Luo |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Hainan Provincial Natural Science Foundation of China |
No. 822RC828 |
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| Corresponding Author |
Wen Luo, MD, PhD, Assistant Professor, Doctor, Doctor, Department of Stomatology, The First Affiliated Hospital of Hainan Medical University, No. 31 Longhua Road, Longhua District, Haikou 570102, Hainan Province, China. luowen228@163.com |
| Key Words |
Dental follicle stem cells; Oral disease; Neurological disease; Tissue engineering; Regeneration; Immunoregulation |
| Core Tip |
This review is intended to summarize and comment on the properties, application potentials, and clinical transformation value of dental follicle stem cells (DFSCs). Stem cells derived from dental SCs (DSCs) originating from the craniofacial neural crest exhibit dental-like tissue differentiation potentials and neuro-ectodermal features, making them a promising alternative for the treatment of oral and neurological diseases. Moreover, in contrast to other DSCs, DFSCs from the early-developing tissues exhibit a number of superior properties, including larger tissue volume, higher cell proliferation rate, more similar biological profiles to progenitor cells of origin, and better anti-inflammatory effects, etc. These advantages are part of the critical mechanism by which DFSCs exert therapeutic effects and are relevant for large scale scaling and industrial generation for clinical applications. Moreover, cryopreservation preserves the biological properties of DFSCs and enables them to be used as off-shelf products for clinical applications. Therefore, DFSCs could have great clinical prospects and translational value in oral and neurological diseases with natural advantages. |
| Publish Date |
2023-04-26 08:16 |
| Citation |
Yang C, Du XY, Luo W. Clinical application prospects and transformation value of dental follicle stem cells in oral and neurological diseases. World J Stem Cells 2023; 15(4): 136-149 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i4/136.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i4.136 |
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