Publication Name	World Journal of Stem Cells
Manuscript ID	82196
Country	China

Received	2022-12-19 07:33
Peer-Review Started	2022-12-19 07:35
To Make the First Decision
Return for Revision	2023-01-06 17:55
Revised	2023-01-18 07:17
Second Decision	2023-03-06 03:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-03-21 07:36
Articles in Press	2023-03-21 07:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-04-18 04:18
Publish the Manuscript Online	2023-04-26 08:16

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Review
Article Title	Clinical application prospects and transformation value of dental follicle stem cells in oral and neurological diseases
Manuscript Source	Invited Manuscript
All Author List	Chao Yang, Xin-Ya Du and Wen Luo
ORCID	Author(s) ORCID Number Chao Yang http://orcid.org/0000-0001-6351-2327 Xin-Ya Du http://orcid.org/0000-0001-6591-037X Wen Luo http://orcid.org/0000-0002-5662-597X
Funding Agency and Grant Number	Funding Agency Grant Number Hainan Provincial Natural Science Foundation of China No. 822RC828
Corresponding Author	Wen Luo, MD, PhD, Assistant Professor, Doctor, Department of Stomatology, The First Affiliated Hospital of Hainan Medical University, No. 31 Longhua Road, Longhua District, Haikou 570102, Hainan Province, China. luowen228@163.com
Key Words	Dental follicle stem cells; Oral disease; Neurological disease; Tissue engineering; Regeneration; Immunoregulation
Core Tip	This review is intended to summarize and comment on the properties, application potentials, and clinical transformation value of dental follicle stem cells (DFSCs). Stem cells derived from dental SCs (DSCs) originating from the craniofacial neural crest exhibit dental-like tissue differentiation potentials and neuro-ectodermal features, making them a promising alternative for the treatment of oral and neurological diseases. Moreover, in contrast to other DSCs, DFSCs from the early-developing tissues exhibit a number of superior properties, including larger tissue volume, higher cell proliferation rate, more similar biological profiles to progenitor cells of origin, and better anti-inflammatory effects, etc. These advantages are part of the critical mechanism by which DFSCs exert therapeutic effects and are relevant for large scale scaling and industrial generation for clinical applications. Moreover, cryopreservation preserves the biological properties of DFSCs and enables them to be used as off-shelf products for clinical applications. Therefore, DFSCs could have great clinical prospects and translational value in oral and neurological diseases with natural advantages.
Publish Date	2023-04-26 08:16
Citation	Yang C, Du XY, Luo W. Clinical application prospects and transformation value of dental follicle stem cells in oral and neurological diseases. World J Stem Cells 2023; 15(4): 136-149
URL	https://www.wjgnet.com/1948-0210/full/v15/i4/136.htm
DOI	https://dx.doi.org/10.4252/wjsc.v15.i4.136

Full Article (PDF)	WJSC-15-136.pdf
Full Article (Word)	WJSC-15-136.docx
Manuscript File	82196_Auto_Edited-JLW.docx
Answering Reviewers	82196-Answering reviewers.pdf
Audio Core Tip	82196-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	82196-Conflict-of-interest statement.pdf
Copyright License Agreement	82196-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	82196-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	82196-Language certificate.pdf
Peer-review Report	82196-Peer-review(s).pdf
Scientific Misconduct Check	82196-Bing-Chen YL-2.png
Scientific Editor Work List	82196-Scientific editor work list.pdf