| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Repetitive administration of cultured human CD34+ cells improve adenine-induced kidney injury in mice
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Takayasu Ohtake, Shoichi Itaba, Amankeldi A Salybekov, Yin Sheng, Tsutomu Sato, Mitsuru Yanai, Makoto Imagawa, Shigeo Fujii, Hiroki Kumagai, Masamitsu Harata, Takayuki Asahara and Shuzo Kobayashi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Takayasu Ohtake, MD, PhD, Director, Director, Doctor, Doctor, Regenerative Medicine, The Center for Cell Therapy & Regenerative Medicine, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura 247-8533, Kanagawa, Japan. ohtake@shonankamakura.or.jp |
| Key Words |
Chronic kidney disease; CD34+ cell; Adenine; Tubulointerstitial injury; Quality and quantity control culture; Umbilical cord blood |
| Core Tip |
There is no established treatment for retarding the progression or improving advanced chronic kidney disease (CKD). Here, we provided effectiveness of cord blood derived cultured human CD34+ cell on progressive CKD model in mice. Kidney function and pathological damage were improved by repetitive cell therapy along with the improvement of microvasculature and inhibition of inflammatory cell infiltration in the kidney. Enhanced cell potential (proliferation and increase of endothelial progenitor cell colony-forming unit) by culture might be a key factor for improving progressive kidney injury. |
| Publish Date |
2023-04-26 08:16 |
| Citation |
Ohtake T, Itaba S, Salybekov AA, Sheng Y, Sato T, Yanai M, Imagawa M, Fujii S, Kumagai H, Harata M, Asahara T, Kobayashi S. Repetitive administration of cultured human CD34+ cells improve adenine-induced kidney injury in mice. World J Stem Cells 2023; 15(4): 268-280 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i4/268.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i4.268 |
