| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Control Study |
| Article Title |
Polymorphism of genes encoding drug-metabolizing and inflammation-related enzymes for susceptibility to cholangiocarcinoma in Thailand
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Gyokukou You, Lu Zeng, Hideaki Tanaka, Emi Ohta, Takahiro Fujii, Kazuhiko Ohshima, Masakazu Tanaka, Nobuyuki Hamajima, Chutiwan Viwatthanasittiphong, Mantana Muangphot, Dhiraphol Chenvidhya, A Jedpiyawongse, Banchob Sripa, Masanao Miwa and Satoshi Honjo |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science |
21406011 |
|
| Corresponding Author |
Satoshi Honjo, MD, MSc, PhD, Chief Doctor, Senior Researcher, Department of Paediatirics, National Hospital Organization, Fukuoka National Hospital, 1-39-4 Yakatabaru, Minami-ku, Fukuoka 811-1394, Fukuoka, Japan. satoshihonjo@hotmail.com |
| Key Words |
Opisthorchis; Glutathione transferase; Cytochrome P-450 CYP2E1; Case-control study |
| Core Tip |
Cholangiocarcinoma (CCA) is an intractable cancer, and its prevalence in northeastern Thailand is the highest worldwide. An inflammatory condition produced by infection with the liver fluke Opisthorchis viverrini (OV) has been associated with CCA risk, but the susceptibility of individuals has not been fully examined. Our study revealed that persons with the GSTT1 wild-type and CYP2E1 c1/c2 + c2/c2 genotype had an increased risk for developing CCA (OR = 3.33, 95%CI: 1.23-9.00). Therefore, both gene-gene interactions and OV infection should be considered as risk factors for cholangiocarcinogenesis. |
| Publish Date |
2023-03-21 03:50 |
| Citation |
You G, Zeng L, Tanaka H, Ohta E, Fujii T, Ohshima K, Tanaka M, Hamajima N, Viwatthanasittiphong C, Muangphot M, Chenvidhya D, Jedpiyawongse A, Sripa B, Miwa M, Honjo S. Polymorphism of genes encoding drug-metabolizing and inflammation-related enzymes for susceptibility to cholangiocarcinoma in Thailand. World J Gastrointest Pathophysiol 2023; 14(2): 21-33 |
| URL |
https://www.wjgnet.com/2150-5330/full/v14/i2/21.htm |
| DOI |
https://dx.doi.org/10.4291/wjgp.v14.i2.21 |
