Publication Name	World Journal of Clinical Oncology
Manuscript ID	8234
Country	United Kingdom

Received	2013-12-22 12:39
Peer-Review Started	2013-12-22 20:53
To Make the First Decision	2014-02-27 11:21
Return for Revision	2014-03-06 09:10
Revised	2014-03-25 23:42
Second Decision	2014-06-03 16:24
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-03 16:43
Articles in Press	2014-06-03 16:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-18 10:12
Publish the Manuscript Online	2014-08-01 15:17

ISSN	2218-4333 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Topic Highlights
Article Title	Evolution of breast cancer therapeutics: Breast tumour kinase’s role in breast cancer and hope for breast tumour kinase targeted therapy
Manuscript Source	Invited Manuscript
All Author List	Haroon A Hussain and Amanda J Harvey
Funding Agency and Grant Number
Corresponding Author	Dr. Amanda J Harvey, Brunel Institute for Cancer Genetics and Pharmacogenomics, Biosciences, Brunel University (London), Kingston Lane, Uxbridge, Middlesex, UB 8 3PH, United Kingdom. amanda.harvey@brunel.ac.uk
Key Words	Breast tumour kinase; Protein tyrosine kinase 6; Breast neoplasms; Targeted molecular therapy; Intracellular signaling peptides and proteins; Protein kinase inhibitors
Core Tip	Breast tumour kinase/protein tyrosine kinase 6 is overexpressed in up to 86% of invasive breast cancers. It plays a key role in regulating a number of cell processes that are involved in the metastatic process. As a kinase involved in both epidermal growth factor and insulin like growth factors signaling, inhibiting its activity could prove to be an effective way to enhance the effects of current targeted treatments. In addition, disrupting the protein-protein interactions central for the kinase-independent aspects of its function may generate an alternative mechanism for selective targeting of breast cancer cells.
Publish Date	2014-08-01 15:17
Citation	Hussain HA, Harvey AJ. Evolution of breast cancer therapeutics: Breast tumour kinase’s role in breast cancer and hope for breast tumour kinase targeted therapy. World J Clin Oncol 2014; 5(3): 299-310
URL	http://www.wjgnet.com/2218-4333/full/v5/i3/299.htm
DOI	http://dx.doi.org/10.5306/wjco.v5.i3.299

Full Article (PDF)	WJCO-5-299.pdf
Full Article (Word)	WJCO-5-299.doc
Manuscript File	8234-Review.docx
Answering Reviewers	8234-Answering reviewers.pdf
Copyright License Agreement	8234-Copyright assignment.pdf
Peer-review Report	8234-Peer reivew(s).pdf
Scientific Misconduct Check	8234-CrossCheck.jpg
Scientific Editor Work List	8234-Scientific editor work list.pdf