| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Lomatogonium rotatum extract alleviates diabetes mellitus rats induced by high-fat, high-sugar diet and streptozotocin
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Li Dai, Sung-Bo Cho, Hui-Fang Li, Li-Sha A, Xiao-Ping Ji, Sirigunqiqige Pan, Ming-Lan Bao, Laxinamujila Bai, Gen-Na Ba and Ming-Hai Fu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82260773, 81803845 |
| Central Government Guided Local Scientific and Technological Development Project |
2021ZY0015 |
| Science and Technology Young Talents Development Project of Inner Mongolia Autonomous Region |
NJYT22048 |
|
| Corresponding Author |
Ming-Hai Fu, PhD, Associate Professor, NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine (Mongolian Medicine), Inner Mongolia Minzu University, No. 996 Xilamulun Street, Horqin District, Tongliao 028000, Inner Mongolia Autonomous Region, China. mfu@imun.edu.cn |
| Key Words |
Mongolian medicine; Lomatogonium rotatum; Type 2 diabetes; Metabolomics; Swertiamarine; Streptozotocin |
| Core Tip |
Lomatogonium rotatum (LR) is traditionally used in Mongolian folk medicine as a hypoglycemic agent, but its evidence-based pharmacological effects and mechanisms of action have not been fully elucidated. An anti-diabetic experiment revealed that the treatment of LR caused diabetic rats’ plasma levels of insulin and glucagon-like peptide 1 (GLP-1) to increase while significantly lowering their blood sugar, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and oral glucose tolerance test. These findings indicated that LR may have a hypoglycemic impact and that its role may be related to changes in the serum metabolites as well as to facilitating the release of insulin and GLP-1, which lower blood glucose and lipid profiles. |
| Publish Date |
2023-06-15 08:52 |
| Citation |
Dai LL, Cho SB, Li HF, A LS, Ji XP, Pan S, Bao ML, Bai L, Ba GN, Fu MH. Lomatogonium rotatum extract alleviates diabetes mellitus rats induced by high-fat, high-sugar diet and streptozotocin. World J Diabetes 2023; 14(6): 846-861 |
| URL |
https://www.wjgnet.com/1948-9358/full/v14/i6/846.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i6.846 |
