| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Possible mechanisms associated with immune escape and apoptosis on anti-hepatocellular carcinoma effect of Mu Ji Fang granules
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Bing Zhang, Yong-Rui Bao, Shuai Wang, Tian-Jiao Li, He Tai, Jia-Peng Leng, Xin-Xin Yang, Bo-Cai Wang and Xian-Sheng Meng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81874342 |
| Natural Science Foundation of Liaoning Province |
2020-MZLH-35 |
|
| Corresponding Author |
Xian-Sheng Meng, PhD, Dean, Professor, College of Pharmacy, Liaoning University of Traditional Chinese Medicine, No. 77 Life one Road, DD Port, Jinpu District, Dalian 116600, Liaoning Province, China. mxsvvv@163.com |
| Key Words |
Mu Ji Fang granules; Hepatocellular carcinoma; Transforming growth factor β1/Mothers against decapentaplegic homolog; Immune escape; H22 tumor-bearing mice; HepG2 cells |
| Core Tip |
Mu Ji Fang Granules (MJF), a Chinese patent medicine, has been used in hepatitis, cirrhosis and hepatocellular carcinoma (HCC) for more than 30 years. MJF was identified with Molecule Network related to High Performance Liquid Chromatography-Electron Spray Ionization-Time of Flight- Mass Spectrometry, and hub potential anti-HCC targets were screened using network pharmacology and pathway enrichment analysis in H22 tumor-bearing mice and HepG2 cells. It was shown that MJF improved body weight gain and tumor inhibition rate, protected immune organs and liver function, affected immunity and apoptosis, up-regulated the Transforming growth factor β1(TGF-β1)/ Mothers against decapentaplegic homolog(SMAD) signaling pathway, and inhibited the effect of TGF-β1 inhibitor (LY364947). |
| Publish Date |
2023-03-15 02:14 |
| Citation |
Zhang YB, Bao YR, Wang S, Li TJ, Tai H, Leng JP, Yang XX, Wang BC, Meng XS. Possible mechanisms associated with immune escape and apoptosis on anti-hepatocellular carcinoma effect of Mu Ji Fang granules. World J Gastrointest Oncol 2023; 15(3): 504-522 |
| URL |
https://www.wjgnet.com/1948-5204/full/v15/i3/504.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i3.504 |
