Publication Name	World Journal of Hepatology
Manuscript ID	82404
Country	Russia

Received	2022-12-17 11:26
Peer-Review Started	2022-12-17 11:28
To Make the First Decision
Return for Revision	2023-01-23 05:23
Revised	2023-02-01 08:36
Second Decision	2023-03-30 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-03-30 09:23
Articles in Press	2023-03-30 09:23
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-03-28 16:35
Typeset the Manuscript	2023-04-17 01:48
Publish the Manuscript Online	2023-04-20 07:26

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Therapeutic possibilities of gut microbiota modulation in acute decompensation of liver cirrhosis
Manuscript Source	Invited Manuscript
All Author List	Dmitry Victorovich Garbuzenko
ORCID	Author(s) ORCID Number Dmitry Victorovich Garbuzenko http://orcid.org/0000-0001-9809-8015
Funding Agency and Grant Number
Corresponding Author	Dmitry Victorovich Garbuzenko, DSc, MD, PhD, Professor, Department of Faculty Surgery, South Ural State Medical University, 64 Vorovskogo Str., Chelyabinsk 454080, Russia. garb@inbox.ru
Key Words	Liver cirrhosis; Acute decompensation; Pathogenesis; Therapy; Gut microbiota; Modulation
Core Tip	Given that particular alterations in the composition and function of gut microbiota play a crucial role in the pathogenesis of acute decompensation in liver cirrhosis, this review summarized the investigations that describe the theoretical foundations and therapeutic potential of gut microbiota modulation in acute decompensation of liver cirrhosis. Despite the encouraging preliminary data, the majority of the suggested strategies have only been tested in animal models or in preliminary clinical trials. Additional multicenter randomized controlled trials must demonstrate their efficacy in larger patient populations.
Publish Date	2023-04-20 07:26
Citation	Garbuzenko DV. Therapeutic possibilities of gut microbiota modulation in acute decompensation of liver cirrhosis. World J Hepatol 2023; 15(4): 525-537
URL	https://www.wjgnet.com/1948-5182/full/v15/i4/525.htm
DOI	https://dx.doi.org/10.4254/wjh.v15.i4.525

Full Article (PDF)	WJH-15-525-with-cover.pdf
Full Article (Word)	WJH-15-525.docx
Manuscript File	82404_Auto_Edited-JRF-Filipodia CL-JLW.docx
Answering Reviewers	82404-Answering reviewers.pdf
Audio Core Tip	82404-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	82404-Conflict-of-interest statement.pdf
Copyright License Agreement	82404-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	82404-Language certificate.pdf
Peer-review Report	82404-Peer-review(s).pdf
Scientific Misconduct Check	82404-Bing-Fan JR-2.png
Scientific Editor Work List	82404-Scientific editor work list.pdf