Publication Name	World Journal of Gastroenterology
Manuscript ID	8248
Country	United States

Received	2013-12-22 13:28
Peer-Review Started	2013-12-23 09:01
To Make the First Decision	2014-02-28 18:04
Return for Revision	2014-03-07 20:23
Revised	2014-03-21 04:49
Second Decision	2014-06-05 10:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-05 10:58
Articles in Press	2014-06-05 11:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-24 20:48
Publish the Manuscript Online	2014-09-07 13:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Advances in the management of peritoneal mesothelioma
Manuscript Source	Invited Manuscript
All Author List	Ali Raza, Wei-Ching Huang and Kazuaki Takabe
Funding Agency and Grant Number	Funding Agency Grant Number United States National Institute of Health R01CA160688 Susan G Komen Investigator Initiated Research Grant IIR12222224 (to Kazuaki Takabe)
Corresponding Author	Kazuaki Takabe, MD, PhD, FACS, Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine and Massey Cancer Center, PO Box 980011, West Hospital 7-402, 1200 East Broad Street, Richmond, VA 23298-0011, United States. ktakabe@vcu.edu
Key Words	Peritoneal mesothelioma; Mesothelioma; Hyperthermic intraperitoneal chemotherapy; Cytoreduction; Sphingosine kinase; Sphingosine-1-phosphate; FTY720
Core Tip	Peritoneal mesothelioma (PM) historically has been associated with a very poor prognosis. Cytoreduction with hyperthermic intraperitoneal chemotherapy improved survival outcomes but carries significant morbidity. Increasingly, research has focused on identifying molecular targets and only a handful have been described; even fewer directed therapies have been evaluated. We review the role of sphingosine kinase 1 and sphingosine-1-phosphate (S1P) signaling in PM and discuss the possibility of targeting it with FTY720, a functional antagonist of S1P Receptor 1. Further investigation is warranted in this new avenue of interest.
Publish Date	2014-09-07 13:31
Citation	Raza A, Huang WC, Takabe K. Advances in the management of peritoneal mesothelioma. World J Gastroenterol 2014; 20(33): 11700-11712
URL	http://www.wjgnet.com/1007-9327/full/v20/i33/11700.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i33.11700

Full Article (PDF)	WJG-20-11700.pdf
Full Article (Word)	WJG-20-11700.doc
Manuscript File	8248-Review.doc
Answering Reviewers	8248-Answering reviewers.pdf
Copyright License Agreement	8248-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	8248-Language certificate.pdf
Peer-review Report	8248-Peer review(s).pdf
Scientific Misconduct Check	8248-CrossCheck.jpg
Scientific Editor Work List	8248-Scientific editor work list.pdf