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Articles Published Processes
9/7/2014 1:30:00 PM | Browse: 1395 | Download: 1779
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Received |
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2013-12-22 13:28 |
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Peer-Review Started |
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2013-12-23 09:01 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-03-07 20:23 |
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Revised |
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2014-03-21 04:49 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-06-05 10:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-06-05 10:58 |
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Articles in Press |
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2014-06-05 11:24 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-08-24 20:48 |
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Publish the Manuscript Online |
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2014-09-07 13:31 |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Advances in the management of peritoneal mesothelioma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ali Raza, Wei-Ching Huang and Kazuaki Takabe |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| United States National Institute of Health |
R01CA160688 |
| Susan G Komen Investigator Initiated Research Grant |
IIR12222224 (to Kazuaki Takabe) |
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| Corresponding Author |
Kazuaki Takabe, MD, PhD, FACS, Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine and Massey Cancer Center, PO Box 980011, West Hospital 7-402, 1200 East Broad Street, Richmond, VA 23298-0011, United States. ktakabe@vcu.edu |
| Key Words |
Peritoneal mesothelioma; Mesothelioma; Hyperthermic intraperitoneal chemotherapy; Cytoreduction; Sphingosine kinase; Sphingosine-1-phosphate; FTY720 |
| Core Tip |
Peritoneal mesothelioma (PM) historically has been associated with a very poor prognosis. Cytoreduction with hyperthermic intraperitoneal chemotherapy improved survival outcomes but carries significant morbidity. Increasingly, research has focused on identifying molecular targets and only a handful have been described; even fewer directed therapies have been evaluated. We review the role of sphingosine kinase 1 and sphingosine-1-phosphate (S1P) signaling in PM and discuss the possibility of targeting it with FTY720, a functional antagonist of S1P Receptor 1. Further investigation is warranted in this new avenue of interest. |
| Publish Date |
2014-09-07 13:31 |
| Citation |
Raza A, Huang WC, Takabe K. Advances in the management of peritoneal mesothelioma. World J Gastroenterol 2014; 20(33): 11700-11712 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i33/11700.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i33.11700 |
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