Publication Name	World Journal of Cardiology
Manuscript ID	82481
Country	United States

Received	2022-12-20 07:42
Peer-Review Started	2022-12-20 07:44
To Make the First Decision
Return for Revision	2023-02-20 07:54
Revised	2023-03-20 03:33
Second Decision	2023-04-25 03:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-04-25 08:57
Articles in Press	2023-04-25 08:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-05-15 06:18
Publish the Manuscript Online	2023-05-19 07:45

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Retrospective Cohort Study
Article Title	Importance of concomitant functional mitral regurgitation on survival in severe aortic stenosis patients undergoing aortic valve replacement
Manuscript Source	Invited Manuscript
All Author List	Ramdas G Pai and Padmini Varadarajan
ORCID	Author(s) ORCID Number Ramdas G Pai http://orcid.org/0000-0002-4155-4566
Funding Agency and Grant Number
Corresponding Author	Ramdas G Pai, FACC, FRCP (Hon), MD, Doctor, Doctor, Professor, Department of Cardiology, University of California Riverside School of Medicine, Riverside/St. Bernardine Medical Center, San Bernardino, Riverside, CA 92507, United States. ramdaspai@yahoo.com
Key Words	Aortic stenosis; Mitral regurgitation; Aortic valve replacement; Long term survival
Core Tip	This study is unique in several aspects: (1) Shows that mitral regurgitation negatively impacts survival in an independent fashion, an effect incremental to left ventricular size and ejection fraction; (2) Perhaps the longest follow up of severe aortic stenosis (AS) patients undergoing aortic valve replacement (AVR) (till death or 16-26 year follow up in survivors); (3) Gives insights into potential mitral regurgitation (MR) mechanisms; and (4) validates echocardiographic MR severity against survival in patients with severe AS undergoing AVR.
Publish Date	2023-05-19 07:45
Citation	Pai RG, Varadarajan P. Importance of concomitant functional mitral regurgitation on survival in severe aortic stenosis patients undergoing aortic valve replacement. World J Cardiol 2023; 15(5): 253-261
URL	https://www.wjgnet.com/1949-8462/full/v15/i5/253.htm
DOI	https://dx.doi.org/10.4330/wjc.v15.i5.253

Full Article (PDF)	WJC-15-253.pdf
Full Article (Word)	WJC-15-253.docx
Manuscript File	82481_Auto_Edited-JLW.docx
Answering Reviewers	82481-Answering reviewers.pdf
Audio Core Tip	82481-Audio core tip.m4a
Biostatistics Review Certificate	82481-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	82481-Conflict-of-interest_statement.pdf
Copyright License Agreement	82481-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document	82481-Institutional review board statement.pdf
Peer-review Report	82481-Peer-review(s).pdf
Scientific Misconduct Check	82481-Bing-Liu XF-2.png
Scientific Editor Work List	82481-Scientific editor work list.pdf
CrossCheck Report	82481-CrossCheck report.pdf