Publication Name	World Journal of Gastroenterology
Manuscript ID	8262
Country	China

Received	2013-12-22 15:19
Peer-Review Started	2013-12-22 23:28
First Decision by Editorial Office Director
Return for Revision	2014-03-07 20:24
Revised	2014-04-03 23:54
Publication Fee Transferred
Second Decision by Editor	2014-05-29 20:15
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-05-29 20:39
Articles in Press	2014-05-29 21:06
Edit the Manuscript by Language Editor	2014-06-18 06:51
Typeset the Manuscript	2014-08-28 09:43
Publish the Manuscript Online	2014-08-29 11:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Randomized Clinical Trial
Article Title	Efficacy of tandospirone in patients with irritable bowel syndrome-diarrhea and anxiety
Manuscript Source	Unsolicited Manuscript
All Author List	Ling Lan, Yu-Long Chen, Hao Zhang, Bai-Ling Jia, Yan-Jun Chu, Jin Wang, Shi-Xiao Tang and Guo-Dong Xia
Funding Agency and Grant Number
Corresponding Author	Correspondence to: Yu-Long Chen, Professor, Department of Gastroenterology, the First Affiliated Hospital, Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou 450052, China. yulongchen@hotmail.com
Key Words	Irritable bowel syndrome; Anxiety; Tandospirone; Efficacy; Safety
Core Tip	Irritable bowel syndrome (IBS) is associated with psychological stress, anxiety and depression, which may contribute to perpetuating the condition. IBS-diarrhea (IBS-D), an isotype of IBS, is often accompanied by anxiety, and conventional therapy is unfavorable. IBS-D may respond positively to anti-anxiety/-depression therapies. However, existing medications are not sufficiently effective for patients with IBS-D. To our knowledge, few randomized, controlled and multi-center studies have focused on the efficacy of anti-anxiety agents in IBS-D patients. This is a prospective, randomized, controlled study to evaluate the efficacy of tandospirone in patients with combined IBS-D and anxiety.
Publish Date	2014-08-29 11:57
Citation	Lan L, Chen YL, Zhang H, Jia BL, Chu YJ, Wang J, Tang SX, Xia GD. Efficacy of tandospirone in patients with irritable bowel syndrome-diarrhea and anxiety. World J Gastroenterol 2014; 20(32): 11422-11428
URL	http://www.wjgnet.com/1007-9327/full/v20/i32/11422.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i32.11422

Full Article (PDF)	WJG-20-11422.pdf
Full Article (Word)	WJG-20-11422.doc
Manuscript File	8262-Review.doc
Answering Reviewers	8262-Answering reviewers.pdf
Copyright License Agreement	8262-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	8262-Language certificate.PDF
Peer-review Report	8262-Peer review(s).pdf
Scientific Misconduct Check	8262-CrossCheck.jpg
Scientific Editor Work List	8262-Scientific editor work list.pdf