| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Competing risks of death in younger and older postmenopausal breast cancer patients
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Judy-Anne W Chapman, Kathleen I Pritchard, Paul E Goss, James N Ingle, Hyman B Muss, Susan F Dent, Ted A Vandenberg, Brian Findlay, Karen A Gelmon, Carolyn F Wilson, Lois E Shepherd and Michael N Pollak |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Canadian Cancer Society through a grant to the NCIC Clinical Trials Group from the Canadian Cancer Society Research Institute |
|
| Novartis provided the NCIC CTG MA.14 drug octreotide LAR |
|
|
| Corresponding Author |
Judy-Anne W Chapman, PhD, Senior Biostatistician, NCIC Clinical Trials Group, Queen's University, 10 Stuart Street, Kingston, ON, K7L 3N6, Canada. jchapman@ctg.queensu.ca |
| Key Words |
Breast cancer; Postmenopausal; Hormone receptor positive; Competing risks; Tamoxifen; Octreotide LAR |
| Core Tip |
With earlier detection and improved therapies, patients with early breast cancer simultaneously face multiple health risks; 54% of women ≥ 70 years at diagnosis died from other causes. Octreotide LAR, an early drug targeting the insulin pathway, might have affected both breast and other cause mortality. We demonstrated a method of jointly assessing the impact of therapy and baseline patient characteristics on multiple causes of death. Older patients with higher body mass index experienced more other cause mortality, while women with smaller hormone receptor positive tumours and less lymph node involvement were less likely to die from breast cancer. |
| Publish Date |
2014-12-11 14:23 |
| Citation |
Chapman JAW, Pritchard KI, Goss PE, Ingle JN, Muss HB, Dent SF, Vandenberg TA, Findlay B, Gelmon KA, Wilson CF, Shepherd LE, Pollak MN. Competing risks of death in younger and older postmenopausal breast cancer patients. World J Clin Oncol 2014; 5(5): 1088-1096 |
| URL |
http://www.wjgnet.com/2218-4333/full/v5/i5/1088.htm |
| DOI |
http://dx.doi.org/10.5306/wjco.v5.i5.1088 |
