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Articles Published Processes
7/25/2023 6:43:29 AM | Browse: 165 | Download: 582
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Received |
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2022-12-29 03:32 |
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Peer-Review Started |
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2022-12-29 03:32 |
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To Make the First Decision |
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Return for Revision |
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2023-04-27 16:25 |
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Revised |
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2023-05-18 17:13 |
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Second Decision |
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2023-06-25 03:34 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-06-25 08:03 |
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Articles in Press |
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2023-06-25 08:03 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-07-19 13:23 |
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Publish the Manuscript Online |
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2023-07-25 06:43 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Developmental Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Commitment of human mesenchymal stromal cells to skeletal lineages is independent of their morphogenetic capacity
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jessica Cristina Marín-Llera, Damián García-García, Estefania Garay-Pacheco, Victor Adrian Cortes-Morales, Juan Jose Montesinos-Montesinos and Jesus Chimal-Monroy |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Dirección General de Asuntos del Personal Académico (DGAPA)-Universidad Nacional Autónoma de México |
IN211117 |
| Consejo Nacional de Ciencia y Tecnología (CONACyT) |
1887 CONACyT-Fronteras de la Ciencia |
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| Corresponding Author |
Jesus Chimal-Monroy, PhD, Research Scientist, Senior Researcher, Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Apartado Postal 70228, Coyoacan 04510, Mexico. jchimal@unam.mx |
| Key Words |
Human mesenchymal stromal cells; Recombinant limbs; Mesenchymal stromal cell morphogenesis; Mesenchymal stromal cell in vivo differentiation; Skeletal tissues |
| Core Tip |
Human mesenchymal stromal cells (MSCs) from umbilical cord blood or placenta can differentiate into osteogenic and chondrogenic lineages in culture systems and have been used in regenerative medicine. Here, we used the recombinant limb (RL) model to provide evidence that MSCs do not have the ability to generate skeletal structures in vivo. MSCs received and responded to the ectoderm’s embryonic spatiotemporal signals in this RL system. However, the expression of differentiation markers of skeletal lineages was not sufficient to generate skeletal structures in vivo. |
| Publish Date |
2023-07-25 06:43 |
| Citation |
Marín-Llera JC, García-García D, Garay-Pacheco E, Adrian Cortes-Morales V, Montesinos-Montesinos JJ, Chimal-Monroy J. Commitment of human mesenchymal stromal cells to skeletal lineages is independent of their morphogenetic capacity. World J Stem Cells 2023; 15(7): 701-712 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i7/701.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i7.701 |
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