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4/14/2023 1:45:13 PM | Browse: 184 | Download: 513
Publication Name World Journal of Gastroenterology
Manuscript ID 82706
Country Japan
Received
2022-12-29 14:35
Peer-Review Started
2022-12-29 14:37
To Make the First Decision
Return for Revision
2023-02-01 06:53
Revised
2023-02-13 03:10
Second Decision
2023-03-28 03:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2023-03-29 18:50
Articles in Press
2023-03-29 18:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-04-10 00:52
Publish the Manuscript Online
2023-04-14 13:45
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Minireviews
Article Title Mechanisms of gastrointestinal barrier dysfunction in COVID-19 patients
Manuscript Source Invited Manuscript
All Author List Weijie Xue, Masaki Honda and Taizo Hibi
ORCID
Author(s) ORCID Number
Masaki Honda http://orcid.org/0000-0001-5526-2591
Taizo Hibi http://orcid.org/0000-0002-6867-228X
Funding Agency and Grant Number
Corresponding Author Masaki Honda, MD, PhD, Assistant Professor, Department of Transplantation and Pediatric Surgery, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan. honda.masaki@kuh.kumamoto-u.ac.jp
Key Words Gastrointestinal barrier dysfunction; SARS-CoV-2; COVID-19; Angiotensin-converting enzyme 2; Microbiome; Immune cells
Core Tip Coronavirus disease 2019 (COVID-19) has become a major global public health event, resulting in a significant social and economic burden. Although COVID-19 was initially characterized as an upper respiratory and pulmonary infection, recent evidence suggests that it is a complex disease including gastrointestinal symptoms. Moreover, it remains unclear whether the gastrointestinal symptoms are caused by direct infection of the gastrointestinal tract by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or are the result of systemic immune activation and subsequent dysregulation of homeostatic mechanisms. This review provides a brief overview of the mechanisms by which SARS-CoV-2 disrupts gastrointestinal barrier integrity.
Publish Date 2023-04-14 13:45
Citation Xue W, Honda M, Hibi T. Mechanisms of gastrointestinal barrier dysfunction in COVID-19 patients. World J Gastroenterol 2023; 29(15): 2283-2293
URL https://www.wjgnet.com/1007-9327/full/v29/i15/2283.htm
DOI https://dx.doi.org/10.3748/wjg.v29.i15.2283
Full Article (PDF) WJG-29-2283.pdf
Full Article (Word) WJG-29-2283.docx
Manuscript File 82706_Auto_Edited-LM.docx
Answering Reviewers 82706-Answering reviewers.pdf
Audio Core Tip 82706-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 82706-Conflict-of-interest statement.pdf
Copyright License Agreement 82706-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 82706-Language certificate.pdf
Peer-review Report 82706-Peer-review(s).pdf
Scientific Misconduct Check 82706-Bing-Yan JP-2.png
Scientific Editor Work List 82706-Scientific editor work list.pdf
CrossCheck Report 82706-CrossCheck report.pdf