Publication Name	World Journal of Stem Cells
Manuscript ID	82729
Country	Australia

Received	2022-12-27 08:24
Peer-Review Started	2022-12-27 08:25
To Make the First Decision
Return for Revision	2023-01-06 17:47
Revised	2023-01-30 08:02
Second Decision	2023-03-17 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-03-20 23:13
Articles in Press	2023-03-20 23:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-04-18 04:17
Publish the Manuscript Online	2023-04-26 08:16

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Human pluripotent stem cell-derived β cells: Truly immature islet β cells for type 1 diabetes therapy?
Manuscript Source	Invited Manuscript
All Author List	Helen Jiang and Fang-Xu Jiang
ORCID	Author(s) ORCID Number Helen Jiang http://orcid.org/0000-0002-5949-141X Fang-Xu Jiang http://orcid.org/0000-0003-3172-0476
Funding Agency and Grant Number	Funding Agency Grant Number Juvenile Diabetes Research Foundation 4-2006-1025 Diabetes Australia Research Trust Telethon Perth Children’s Hospital Research Fund (TPCHRF)
Corresponding Author	Fang-Xu Jiang, PhD, Adjunct Associate Professor, School of Biomedical Sciences, University of Western Australia, 35 Stirling Hwy, Crawley WA 6009, Perth 6009, Australia. fang-xu.jiang@perkins.uwa.edu.au
Key Words	Human pluripotent stem cells; Stem cell-derived β cells; Islet β cells; Type 1 diabetes mellitus; Cell replacement therapy
Core Tip	Diabetes mellitus (DM) is a metabolic condition of absolute or relative deficiency in insulin. Since the discovery of insulin 100 years ago, there has been slow progress in the treatment of type 1 DM (T1DM) in clinical practice. In the scientific community however, there is much interest and progression in the research of human pluripotent stem cell derived insulin producing β-like cells, pervasively known as stem cell-derived β cells (SC-β cells). If they are determined to be genuine, scalable and functionally matured, SC-β cells have the potential to cure T1DM through cell replacement therapy.
Publish Date	2023-04-26 08:16
Citation	Jiang H, Jiang FX. Human pluripotent stem cell-derived β cells: Truly immature islet β cells for type 1 diabetes therapy? World J Stem Cells 2023; 15(4): 182-195
URL	https://www.wjgnet.com/1948-0210/full/v15/i4/182.htm
DOI	https://dx.doi.org/10.4252/wjsc.v15.i4.182

Full Article (PDF)	WJSC-15-182.pdf
Full Article (Word)	WJSC-15-182.docx
Manuscript File	82729_Auto_Edited-LM.docx
Answering Reviewers	82729-Answering reviewers.pdf
Audio Core Tip	82729-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	82729-Conflict-of-interest statement.pdf
Copyright License Agreement	82729-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	82729-Grant application form(s).pdf
Peer-review Report	82729-Peer-review(s).pdf
Scientific Misconduct Check	82729-Bing-Wang JJ-2.png
Scientific Editor Work List	82729-Scientific editor work list.pdf
CrossCheck Report	82729-CrossCheck report.pdf