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Articles Published Processes
5/26/2023 11:17:59 AM | Browse: 220 | Download: 659
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Received |
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2023-01-14 06:06 |
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Peer-Review Started |
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2023-01-14 06:07 |
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To Make the First Decision |
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Return for Revision |
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2023-03-21 16:42 |
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Revised |
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2023-03-31 17:10 |
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Second Decision |
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2023-04-23 03:24 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-04-24 02:56 |
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Articles in Press |
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2023-04-24 02:56 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-05-17 08:41 |
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Publish the Manuscript Online |
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2023-05-26 11:17 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Modulation of stem cell fate in intestinal homeostasis, injury and repair
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Zhe Wang, Yan-Ji Qu and Min Cui |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
82202766 |
| the Natural Science Foundation of Hubei Province of China |
2022CFB686 |
| the Science Foundation of Union Hospital |
2021xhyn102 |
| the Scientific Research Training Program for Young Talents in Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China |
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| Corresponding Author |
Min Cui, MD, PhD, Associate Chief Physician, Associate Professor, Doctor, Doctor, Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. cm95588@hust.edu.cn |
| Key Words |
Intestinal stem cell; Epithelial repair; Homeostasis; Regeneration; Self-renewal; Apoptosis |
| Core Tip |
The homeostatic repair and regeneration of the intestinal epithelium upon injury are governed by the Lgr5+ intestinal stem cells (ISCs) located at the base of crypts, which fuel rapid renewal and give rise to different epithelial cell types. We review the current understanding of the intrinsic niche signaling and extrinsic stimulating factors that control homeostasis and regeneration of the ISCs. Deciphering the regulatory machinery that modulates stem cell fate, and formulating strategies for better repair and regeneration would aid in the development of novel therapeutics that promote facilitate mucosal healing and restore epithelial barrier function. |
| Publish Date |
2023-05-26 11:17 |
| Citation |
Wang Z, Qu YJ, Cui M. Modulation of stem cell fate in intestinal homeostasis, injury and repair. World J Stem Cells 2023; 15(5): 354-368 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i5/354.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i5.354 |
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