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Articles Published Processes
6/8/2023 9:24:51 AM | Browse: 207 | Download: 600
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Received |
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2022-12-30 19:29 |
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Peer-Review Started |
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2022-12-30 19:30 |
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To Make the First Decision |
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Return for Revision |
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2023-01-20 02:44 |
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Revised |
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2023-02-03 14:43 |
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Second Decision |
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2023-04-23 03:24 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-04-24 02:54 |
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Articles in Press |
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2023-04-24 02:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-06-02 06:52 |
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Publish the Manuscript Online |
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2023-06-08 09:24 |
| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Rheumatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
IFIH1 and DDX58 gene variants in pediatric rheumatic diseases
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rinat Raupov, Evgeny Suspitsin, Konstantin Belozerov, Tatiana Gabrusskaya and Mikhail Kostik |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mikhail Kostik, MD, PhD, Professor, Department of Pediatry, Saint-Petersburg State Pediatric Medical University, Lytovskaya 2, Saint-Petersburg 194100, Russia. kost-mikhail@yandex.ru |
| Key Words |
IFIH1; DDX58; Undifferentiated systemic autoinflammatory disease; Systemic lupus erythematosus; Interferon-I score |
| Core Tip |
Interferon (IFN) I signaling pathway is the important part of innate immune system and antiviral defense. It’s known that defects in the components of IFN I signaling system can leads to its hyperactivation. This pathogenetic phenomenon is considered as one of the most important in the pathogenesis of immune-mediated diseases, such as systemic lupus erythematosus, dermatomyositis, systemic autoinflammatory diseases. From database containing 92 patients with different rheumatic diseases, whom clinical exome sequencing was performed we selected 14 children (10 girls and 4 boys): 7 patients had DDX58 and 7 had IFIH1 gene variants. The majority of patient with different DDX58 and IFI1 variants had hyperactivation of IFN I signaling pathway. |
| Publish Date |
2023-06-08 09:24 |
| Citation |
Raupov R, Suspitsin E, Belozerov K, Gabrusskaya T, Kostik M. IFIH1 and DDX58 gene variants in pediatric rheumatic diseases. World J Clin Pediatr 2023; 12(3): 107-114 |
| URL |
https://www.wjgnet.com/2219-2808/full/v12/i3/107.htm |
| DOI |
https://dx.doi.org/10.5409/wjcp.v12.i3.107 |
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