Publication Name	World Journal of Gastroenterology
Manuscript ID	82943
Country	Brazil

Received	2022-12-30 23:17
Peer-Review Started	2022-12-30 23:19
To Make the First Decision
Return for Revision	2023-01-22 06:08
Revised	2023-02-14 23:54
Second Decision	2023-04-04 03:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-04-04 08:37
Articles in Press	2023-04-04 08:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-05-05 06:39
Publish the Manuscript Online	2023-05-11 08:05

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Anatomy & Morphology
Manuscript Type	Review
Article Title	Study of tumor necrosis factor receptor in the inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Roberta Figueiroa Souza, Marcos Antônio Ferreira Caetano, Henrique Inhauser Riceti Magalhães and Patricia Castelucci
ORCID	Author(s) ORCID Number Roberta Figueiroa Souza http://orcid.org/0000-0003-4380-6373 Marcos Antônio Ferreira Caetano http://orcid.org/0000-0002-9981-3241 Henrique Inhauser Riceti Magalhães http://orcid.org/0000-0001-9151-8160 Patricia Castelucci http://orcid.org/0000-0002-7475-5962
Funding Agency and Grant Number	Funding Agency Grant Number Research Support Foundation of the State of São Paulo, Brazil 2014/25927-2 Research Support Foundation of the State of São Paulo, Brazil 2018/07862-1 National Council for Scientific and Technological Development (CNPq, Brazil) Higher Education Personnel Improvement Coordination (CAPES, Brazil)
Corresponding Author	Patricia Castelucci, MHSc, PhD, Associate Professor, Associate Research Scientist, Lecturer, Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, Av. Dr. Lineu Prestes, 2415, São Paulo 05508-000, Brazil. pcastel@usp.br
Key Words	Tumor necrosis factor 1 receptor; Tumor necrosis factor 2 receptor; Inflammatory bowel diseases; Enteric nervous system; tumor necrosis factor-alpha
Core Tip	This review summarizes the role of Tumor Necrosis Factor-alpha (TNF-α) in promoting inflammation. Studies have suggested that TNF-α is one of the main pro-inflammatory cytokines involved in the pathogenesis of IBD. In addition, the enteric nervous system is affected by IBD. There are two receptors for TNF: the tumor necrosis factor 1 receptor; and the tumor necrosis factor 2 receptor. They are involved in the pathogenesis of IBD. The application of antibodies aimed at neutralizing TNF-α in patients with IBD induce a satisfactory clinical recovery. This review addresses the main aspects of TNF-α in IBD and anti-TNF therapies.
Publish Date	2023-05-11 08:05
Citation	Souza RF, Caetano MAF, Magalhães HIR, Castelucci P. Study of tumor necrosis factor receptor in the inflammatory bowel disease. World J Gastroenterol 2023; 29(18): 2733-2746
URL	https://www.wjgnet.com/1007-9327/full/v29/i18/2733.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i18.2733

Full Article (PDF)	WJG-29-2733.pdf
Full Article (Word)	WJG-29-2733.docx
Manuscript File	82943_Auto_Edited-JLW.docx
Answering Reviewers	82943-Answering reviewers.pdf
Audio Core Tip	82943-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	82943-Conflict-of-interest statement.pdf
Copyright License Agreement	82943-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	82943-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	82943-Language certificate.pdf
Peer-review Report	82943-Peer-review(s).pdf
Scientific Misconduct Check	82943-Bing-Chang KL-2.png
Scientific Editor Work List	82943-Scientific editor work list.pdf
CrossCheck Report	82943-CrossCheck report.pdf