| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Helicobacter pylori plays a key role in gastric adenocarcinoma induced by spasmolytic polypeptide-expressing metaplasia
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Mian-Li Li, Xin-Xin Hong, Wei-Jian Zhang, Yi-Zhong Liang, Tian-Tian Cai, Yi-Fei Xu, Hua-Feng Pan, Jian-Yuan Kang, Shao-Ju Guo and Hai-Wen Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Guangdong Basic and Applied Basic Research Foundation |
2020A1515110947 |
| the National Natural Science Foundation of China |
82104747 |
| the Scientific Research Project of Guangdong Bureau of Traditional Chinese Medicine |
20231303 |
| the Guangdong Provincial Key Research and Development Plan |
2020B1111100011 |
|
| Corresponding Author |
Hai-Wen Li, MD, Professor, Department of Gastroenterology, Shenzhen Traditional Chinese Medicine Hospital, No. 1 Fuhua Road, Futian District, Shenzhen 518033, Guangdong Province, China. 370062941@qq.com |
| Key Words |
Gastric cancers; Helicobacter pylori; Intestinal metaplasia; Macrophages; Spasmolytic polypeptide-expressing metaplasia |
| Core Tip |
Spasmolytic polypeptide-expressing metaplasia (SPEM), induced by Heliobacter pylori (H. pylori) infection in humans, is strongly associated with gastric adenocarcinoma. Chronic inflammation and immune responses caused by H. pylori infection play important roles in the malignant progression of SPEM. Recent studies suggest that CD44 variant 9 and whey acidic protein 4-disulfide core domain protein 2 expressed by SPEM leads to M2 macrophage recruitment. Furthermore, M2 macrophages upregulate the expression of interleukin 33, which eventually promotes malignant progression. |
| Publish Date |
2023-06-02 11:04 |
| Citation |
Li ML, Hong XX, Zhang WJ, Liang YZ, Cai TT, Xu YF, Pan HF, Kang JY, Guo SJ, Li HW. Helicobacter pylori plays a key role in gastric adenocarcinoma induced by spasmolytic polypeptide-expressing metaplasia. World J Clin Cases 2023; 11(16): 3714-3724 |
| URL |
https://www.wjgnet.com/2307-8960/full/v11/i16/3714.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v11.i16.3714 |
