Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	83001
Country	Malaysia

Received	2023-01-03 08:56
Peer-Review Started	2023-01-03 08:58
First Decision by Editorial Office Director	2023-02-13 23:54
Return for Revision	2023-02-13 23:54
Revised	2023-02-17 10:32
Publication Fee Transferred
Second Decision by Editor	2023-04-21 03:02
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2023-04-21 08:01
Articles in Press	2023-04-21 08:01
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-05-08 00:34
Publish the Manuscript Online	2023-05-12 09:13

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Basic Study
Article Title	BZD9L1 benzimidazole analogue hampers colorectal tumor progression by impeding angiogenesis
Manuscript Source	Invited Manuscript
All Author List	Chern Ein Oon, Ayappa V Subramaniam, Lik Yang Ooi, Ashwaq Hamid Salem Yehya, Yeuan Ting Lee, Gurjeet Kaur, Sreenivasan Sasidharan, Beiying Qiu and Xiaomeng Wang
ORCID	Author(s) ORCID Number Chern Ein Oon http://orcid.org/0000-0002-4685-6408 Gurjeet Kaur http://orcid.org/0000-0002-6232-5703
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Higher Education Malaysia for the Fundamental Research Grant Scheme FRGS/1/2021/SKK06/USM/02/7
Corresponding Author	Chern Ein Oon, DPhil, PhD, Associate Professor, Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Gelugor, Penang 11800, Malaysia. chern.oon@usm.my
Key Words	Colorectal cancer; BZD9L1; Sirtuin; Benzimidazole; Angiogenesis
Core Tip	BZD9L1 hampered EA.hy926 endothelial cell functions through cell cycle arrest and induction of apoptosis. BZD9L1 also reduced the cell adhesion, sirtuin 1 (SIRT1) and SIRT2 gene expression in endothelial cells (EC) compared to the negative control. The compound down-regulated angiogenin, basic fibroblast growth factor, platelet-derived growth factor, and placental growth factor proteins in EC and impeded HCT116 colorectal cancer (CRC) invasion compared to the negative control group. BZD9L1 negatively impacted choroidal sprouting and CRC tumor angiogenesis in vivo compared to the vehicle control group. BZD9L1 reduced tumor necrosis, Ki-67 proliferation marker, hSIRT1, hSIRT2, murine cluster of differentiation 31 (mCD31), mCD34 and murine SIRT2 (mSIRT2) gene expression compared to vehicle control. Findings from this study may provide insights for the BZD9L1 benzimidazole analogue to be further explored as a potential anti-angiogenic agent in CRC.
Publish Date	2023-05-12 09:13
Citation	Oon CE, Subramaniam A, Ooi LY, Yehya A, Lee YT, Kaur G, Sreenivasan S, Qiu BY, Wang XM. BZD9L1 benzimidazole analogue hampers colorectal tumor progression by impeding angiogenesis. World J Gastrointest Oncol 2023; 15(5): 810-827
URL	https://www.wjgnet.com/1948-5204/full/v15/i5/810.htm
DOI	https://dx.doi.org/10.4251/wjgo.v15.i5.810

Full Article (PDF)	WJGO-15-810.pdf
Full Article (Word)	WJGO-15-810.docx