Publication Name	World Journal of Clinical Oncology
Manuscript ID	8311
Country	Greece

Received	2013-12-25 09:26
Peer-Review Started	2013-12-25 16:20
To Make the First Decision	2014-02-13 16:25
Return for Revision	2014-02-20 10:26
Revised	2014-02-23 16:05
Second Decision	2014-03-17 14:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-17 14:48
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-24 14:04
Typeset the Manuscript	2014-05-07 14:40
Publish the Manuscript Online	2014-05-12 18:06

ISSN	2218-4333 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Topic Highlights
Article Title	Micro-RNAs as clinical biomarkers and therapeutic targets in breast cancer: Quo vadis?
Manuscript Source	Invited Manuscript
All Author List	Gerasimos Socrates Christodoulatos and Maria Dalamaga
Funding Agency and Grant Number
Corresponding Author	The specific aberrant expression patterns of micro-RNAs (miRNAs) in breast cancer (BC) that are detected with the use of high-throughput technologies reflect their key role in cancer initiation, progression, migration, invasion and metastasis. The detection of circulating extracellular miRNAs in plasma of BC patients may provide novel, non-invasive biomarkers in favor of BC diagnosis and prognosis and, at the same time, accumulating evidence has underscored the possible contribution of miRNAs as valuable biomarkers to predict response to chemotherapy or radiotherapy. Data from in vitro and in vivo studies on BC have revealed promising therapeutic approaches via miRNA delivery and miRNA inhibition.
Key Words	Biomarker; Breast cancer; Cancer diagnosis; Micro-RNA; Oncogene; Therapy; Tumor suppressor
Core Tip	The specific aberrant expression patterns of miRNAs in BC, that are detected with the use of high-throughput technologies, reflect their key role in cancer initiation, progression, migration, invasion and metastasis. The detection of circulating extracellular miRNAs in plasma of BC patients may provide novel, non-invasive biomarkers in favor of BC diagnosis and prognosis and, at the same time, accumulating evidence has underscored the possible contribution of miRNAs as valuable biomarkers to predict response to chemotherapy or radiotherapy. Data from in vitro and in vivo studies on BC have revealed promising therapeutic approaches via miRNA delivery and miRNA inhibition.
Publish Date	2014-05-12 18:06
Citation	Christodoulatos GS, Dalamaga M. Micro-RNAs as clinical biomarkers and therapeutic targets in breast cancer: Quo vadis? World J Clin Oncol 2014; 5(2): 71-81
URL	http://www.wjgnet.com/2218-4333/full/v5/i2/71.htm
DOI	http://dx.doi.org/10.5306/wjco.v5.i2.71

Full Article (PDF)	WJCO-5-71.pdf
Full Article (Word)	WJCO-5-71.doc
Manuscript File	8311-Review.docx
Answering Reviewers	8311-Answering reviewers.pdf
Copyright License Agreement	8311-Copyright assignment.pdf
Peer-review Report	8311-Peer reviewer(s).pdf
Scientific Editor Work List	8311-Scientific editor work list.doc