| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Risk of gastric cancer is associated with PRKAA1 gene polymorphisms in Koreans
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yong-Dae Kim, Dong-Hyuk Yim, Sang-Yong Eom, Sun In Moon, Hyo-Yung Yun, Young-Jin Song, Sei-Jin Youn, Taisun Hyun, Joo-Seung Park, Byung Sik Kim, Jong-Young Lee, Hee Kwan Won and Heon Kim |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National R & D Program for Cancer Control, Ministry of Health and Welfare, South Korea |
1120330 |
|
| Corresponding Author |
Heon Kim, Professor, Department of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk National University, 52 Naesudong-ro, Hungdok-gu, Cheongju 361-763, South Korea. kimheon@cbu.ac.kr |
| Key Words |
AMP-activated protein kinase; Gastric cancer; PRKAA1; Single nucleotide polymorphism; Case-control study |
| Core Tip |
There were a few studies to evaluate association between PRKAA1 gene and gastric cancer. However, in previous study, only one single nucleotide polymorphism (SNP) (rs13361707) of PRKAA1 gene was focused. The purpose of this study was to evaluate the association between 5 SNPs of the gene encoding AMP-activated protein kinase (PRKAA1) and the risk of gastric cancer. All SNPs in the model showed a dose-response relationship between the minor allele frequency and the risk of gastric cancer. The PRKAA1 gene showed a significant gene-based association with gastric cancer in the versatile gene-based association study test. |
| Publish Date |
2014-07-14 17:39 |
| Citation |
Kim YD, Yim DH, Eom SY, Moon SI, Yun HY, Song YJ, Youn SJ, Hyun T, Park JS, Kim BS, Lee JY, Won HK, Kim H. Risk of gastric cancer is associated with PRKAA1 gene polymorphisms in Koreans. World J Gastroenterol 2014; 20(26): 8592-8598 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i26/8592.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i26.8592 |
