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Articles Published Processes
6/28/2023 10:03:21 AM | Browse: 106 | Download: 288
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Received |
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2023-01-18 15:01 |
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Peer-Review Started |
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2023-01-18 15:05 |
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To Make the First Decision |
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Return for Revision |
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2023-03-26 04:31 |
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Revised |
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2023-04-08 18:10 |
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Second Decision |
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2023-05-12 03:07 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-05-12 09:11 |
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Articles in Press |
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2023-05-12 09:11 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-06-14 01:52 |
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Publish the Manuscript Online |
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2023-06-28 10:03 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Mechanism of ELL-associated factor 2 and vasohibin 1 regulating invasion, migration, and angiogenesis in colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ming-Liang Feng, Ming-Jun Sun, Bo-Yang Xu, Meng-Yuan Liu, Hui-Jing Zhang and Can Wu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Can Wu, PhD, Associate Research Scientist, Attending Doctor, Department of Endoscopy, The First Hospital Affiliated to China Medical University, No. 155 Nanjing North Street, Shenyang 110001, Liaoning Province, China. wucanydyy@163.com |
| Key Words |
ELL-associated factor 2; Vasohibin 1; Transforming growth factor-β1; Signal transducer and activator of transcription 3; Colorectal cancer; Angiogenesis |
| Core Tip |
Endothelial cell-derived vasohibin 1 (VASH1) can regulate tumor angiogenesis and lymphangiogenesis, and tumor cell-derived VASH1 also has a potential functional role in inhibiting cancer cell proliferation and invasion. Knockdown of VASH1 enhanced transforming growth factor beta 1 (TGF-β)/Smad3 pathway activity and type I/III collagen production. Our previous findings suggest that ELL-associated factor 2 (EAF2) may play a tumor suppressor and protective role in the development and progression of colorectal cancer (CRC) by regulating signal transducer and activator of transcription 3 (STAT3)/TGF-β1 signaling pathway. In this study, we found that EAF2 was down-regulated and VASH1 was up-regulated in advanced CRC tissue compared to normal colorectal tissue by immunohistochemistry and Western blot. And the expression levels of EAF2 and VASH1 were positively correlated in advanced CRC tissue. Furthermore, in vitro cellular mechanism studies suggest that overexpression of EAF2 may inhibit the activity of STAT3/TGF-β1 pathway by up-regulating the expression of VASH1, thereby attenuating the invasion, migration and angiogenesis of CRC cells. This study provides new ideas and theoretical basis for the development of new diagnostic markers for CRC and the exploration of the mechanism of targeted therapy. |
| Publish Date |
2023-06-28 10:03 |
| Citation |
Feng ML, Sun MJ, Xu BY, Liu MY, Zhang HJ, Wu C. Mechanism of ELL-associated factor 2 and vasohibin 1 regulating invasion, migration, and angiogenesis in colorectal cancer. World J Gastroenterol 2023; 29(24): 3770-3792 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i24/3770.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i24.3770 |
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