| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Review |
| Article Title |
Core fucosylation and its roles in gastrointestinal glycoimmunology
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Nian-Zhu Zhang, Li-Fen Zhao, Qian Zhang, Hui Fang, Wan-Li Song, Wen-Zhe Li, Yu-Song Ge and Peng Gao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
32171279 |
| Natural Science Foundation of Liaoning Province |
2022-BS-254 |
| Natural Science Foundation of Liaoning Province |
2022-MS-317 |
| Project of Dalian Medical Science Research |
2012026 |
|
| Corresponding Author |
Peng Gao, MD, PhD, Director, Director, Professor, Clinical Laboratory, The Second Hospital of Dalian Medical University, No. 467 Zhongshan Road, Shahekou District, Dalian 116023, Liaoning Province, China. gaop@dicp.ac.cn |
| Key Words |
Fucosyltransferase 8; Core fucosylation; Glycoimmunology; Gastrointestinal tumor immunology; T cell signal pathway |
| Core Tip |
Core fucosylation is driven by fucosyltransferase 8 (Fut8), which catalyzes the addition of α-1,6-fucose to the innermost GlcNAc residue of N-glycans. Core fucosylation plays a vital role in immune responses. Most immune system molecules are core fucosylated glycoproteins that play important roles in antigen recognition and clearance, cell adhesion, lymphocyte activation, apoptosis, signal transduction, and endocytosis. Fut8 is involved in humoral immune responses, cellular immunity, mucosal immunity, and tumor immunology. Here, we summarize the roles and potential modulatory mechanisms of Fut8 in various immune responses of the gastrointestinal system. |
| Publish Date |
2023-07-12 11:13 |
| Citation |
Zhang NZ, Zhao LF, Zhang Q, Fang H, Song WL, Li WZ, Ge YS, Gao P. Core fucosylation and its roles in gastrointestinal glycoimmunology. World J Gastrointest Oncol 2023; 15(7): 1119-1134 |
| URL |
https://www.wjgnet.com/1948-5204/full/v15/i7/1119.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i7.1119 |
