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Articles Published Processes
8/22/2014 2:47:00 PM | Browse: 640 | Download: 763
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Received |
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2013-12-26 09:19 |
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Peer-Review Started |
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2013-12-26 11:09 |
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To Make the First Decision |
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2014-01-17 12:38 |
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Return for Revision |
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2014-01-20 22:02 |
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Revised |
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2014-04-11 23:09 |
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Second Decision |
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2014-05-16 17:40 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-05-16 18:00 |
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Articles in Press |
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2014-05-23 09:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-06-25 09:10 |
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Publish the Manuscript Online |
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2014-06-26 14:40 |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Observational Study |
| Article Title |
Respiratory modulation of cardiac vagal tone in Lyme disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Basant K Puri, Mussadiq Shah, Jean A Monro, Michele C Kingston and Peter OO Julu |
| Funding Agency and Grant Number |
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| Corresponding Author |
Basant K Puri, MA, PhD, MB, BChir, BSc (Hons) MathSci, DipStat, MMath, FRCPsych, FSB, Professor, Imaging Directorate, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0HS, United Kingdom. basant.puri@imperial.ac.uk |
| Key Words |
Cardiac vagal tone; Lyme disease |
| Core Tip |
Given that immune dysfunction, postural orthostatic tachycardia syndrome, fatigue, cognitive dysfunction, orthostatic palpitations, syncope, and stress, which may occur in Lyme disease, are associated with parasympathetic activity and reduced modulation of cardiac vagal tone, we hypothesized that modulation of cardiac vagal tone is impaired in this disease. This was confirmed in our study of 18 patients and 18 matched controls. Cardiac vagal tone is reflexly generated through arterial baroreceptor stimulation, by the afferents of the latter facilitating cardiac vagal motoneuron discharge relaying through interneurons in the nucleus tractus solitarius, implying that Lyme disease may directly affect the vagus or brainstem. |
| Publish Date |
2014-06-26 14:40 |
| Citation |
Puri BK, Shah M, Monro JA, Kingston MC, Julu POO. Respiratory modulation of cardiac vagal tone in Lyme disease. World J Cardiol 2014; 6(6): 502-506 |
| URL |
http://www.wjgnet.com/1949-8462/full/v6/i6/502.htm |
| DOI |
http://dx.doi.org/10.4330/wjc.v6.i6.502 |
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