| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Spatial cluster mapping and environmental modeling in pediatric inflammatory bowel disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Mielle Michaux, Justin M Chan, Luke Bergmann, Luis F Chaves, Brian Klinkenberg and Kevan Jacobson |
| ORCID |
|
| Funding Agency and Grant Number |
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| Corresponding Author |
Kevan Jacobson, AGAF, FRCPC, MBChB, Professor, Senior Scientist, Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Faculty of Medicine, British Columbia Children’s Hospital, University of British Columbia, 4480 Oak Street, Room K4-184, Vancouver V6H 3V4, British Columbia, Canada. kjacobson@cw.bc.ca |
| Key Words |
Inflammatory bowel diseases; Crohn disease; Ulcerative colitis; Pesticides; Air pollution; South Asian people |
| Core Tip |
Utilizing spatial mapping methodology, high and low incidence clusters of pediatric inflammatory bowel disease (IBD) were identified in British Columbia, Canada. Associating geographical location with IBD, rurality was negatively associated with ulcerative colitis. Notably, no high incidence hot spots were detected in the densest urban areas, suggesting unexplored urban protective factors. Novel risk factors for PIBD and specifically Crohn’s disease included fine particulate matter pollution and agricultural applications of petroleum oil to orchards and grapes. Spatial distribution was partially explained by rurality, population ethnicity, family size, pesticide applications, air pollution, ultraviolet exposure, and residential greenness. |
| Publish Date |
2023-06-16 09:52 |
| Citation |
Michaux M, Chan JM, Bergmann L, Chaves LF, Klinkenberg B, Jacobson K. Spatial cluster mapping and environmental modeling in pediatric inflammatory bowel disease. World J Gastroenterol 2023; 29(23): 3688-3702 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i23/3688.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i23.3688 |
