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Articles Published Processes
5/26/2023 11:17:59 AM | Browse: 238 | Download: 535
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Received |
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2023-01-27 15:38 |
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Peer-Review Started |
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2023-01-27 15:42 |
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To Make the First Decision |
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Return for Revision |
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2023-02-28 15:42 |
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Revised |
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2023-03-07 08:28 |
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Second Decision |
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2023-04-13 03:11 |
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Accepted by Journal Editor-in-Chief |
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2023-04-15 18:52 |
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Accepted by Executive Editor-in-Chief |
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2023-04-17 08:38 |
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Articles in Press |
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2023-04-17 08:38 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-05-17 08:42 |
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Publish the Manuscript Online |
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2023-05-26 11:17 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Different priming strategies improve distinct therapeutic capabilities of mesenchymal stromal/stem cells: Potential implications for their clinical use
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Vitale Miceli, Giovanni Zito, Matteo Bulati, Alessia Gallo, Rosalia Busà, Gioacchin Iannolo and Pier Giulio Conaldi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Vitale Miceli, PhD, Academic Editor, Research Scientist, Department of Research, IRCCS ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta Specializzazione), Via Tricomi 5, Palermo 90127, Italy. vmiceli@ismett.edu |
| Key Words |
Mesenchymal stromal/stem cells; Mesenchymal stromal/stem cell therapeutic properties; Mesenchymal stromal/stem cell paracrine effects; Mesenchymal stromal/stem cell priming; Pro-inflammatory priming; Hypoxic priming, 3D culture priming |
| Core Tip |
Mesenchymal stromal/stem cells (MSCs) have demonstrated promising therapeutic results in the field of regenerative medicine. However, due to their heterogeneity, the application of MSCs in clinical trials has shown moderate or poor efficacy. Here, we review data on the principal priming approaches for enhancing the therapeutic potential of MSCs. We found that different priming strategies can modify MSC properties and, in this case some therapeutic effects on different disease models can be obtained in relation to dose and/or combination of the priming factors used. The production of priming type-specific functional factors in MSCs could pave the way toward implementing new MSC-based therapies. |
| Publish Date |
2023-05-26 11:17 |
| Citation |
Miceli V, Zito G, Bulati M, Gallo A, Busà R, Iannolo G, Conaldi PG. Different priming strategies improve distinct therapeutic capabilities of mesenchymal stromal/stem cells: Potential implications for their clinical use. World J Stem Cells 2023; 15(5): 400-420 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i5/400.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i5.400 |
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