| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Liver histopathological lesions is severe in patients with normal alanine transaminase and low to moderate hepatitis B virus DNA replication
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Su-Wen Jiang, Xiang Lian, Ai-Rong Hu, Jia-Lin Lu, Zhe-Yun He, Xiao-Jun Shi, De-Dong Zhu, Zong-Yi Wang and Guan-Cheng Huang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Zhejiang Provincial Basic and Public Welfare Foundation |
LGF22H030002 |
| Ningbo Science and Technology Program |
2021S182 |
| Major Medical Scientific Research Foundation of National Health Commission of the People's Republic of China - Zhejiang Province |
WKJ-ZJ-2341 |
| Zhejiang Province and Ningbo City Co-constructed Project of Leading Medical & Health Discipline |
2016-S04 |
|
| Corresponding Author |
Ai-Rong Hu, MD, Doctor, Ningbo Institute of Liver Diseases, Ningbo No. 2 Hospital, No. 41 Xibei Street, Haishu District, Ningbo 315020, Zhejiang Province, China. huairong@ucas.edu.cn |
| Key Words |
Chronic hepatitis B; Hepatitis B virus DNA; Histology; Risk factors |
| Core Tip |
According to the guidelines, for patients with normal alanine transaminase (ALT), hepatitis B virus (HBV) DNA levels were defined as ≥ 107/2 × 107 and < 2 × 103 IU/mL in the ‘immune-tolerant’ and the ‘inactive-carrier’ phase, respectively. However, it is still controversial. In this study, we analyzed the liver histopathology and the risk factors in 634 cases with positive HBV DNA and normal ALT. We found that patients with low or moderate HBV DNA level had more severe liver diseases. HBV DNA level (negative correlation) was an independent risk factor for liver histopathological severity. Therefore, we consider that the phase definition of chronic hepatitis B may be revised based on whether the level of HBV DNA exceeds the detection low limit value. |
| Publish Date |
2023-04-24 11:14 |
| Citation |
Jiang SW, Lian X, Hu AR, Lu JL, He ZY, Shi XJ, Zhu DD, Wang ZY, Huang GC. Liver histopathological lesions is severe in patients with normal alanine transaminase and low to moderate hepatitis B virus DNA replication. World J Gastroenterol 2023; 29(16): 2479-2494 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i16/2479.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i16.2479 |
