BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
6/15/2023 6:05:28 AM | Browse: 275 | Download: 1399
 |
Received |
|
2023-02-01 11:35 |
|
Peer-Review Started |
|
2023-02-01 11:37 |
|
First Decision by Editorial Office Director |
|
2023-02-16 23:33 |
|
Return for Revision |
|
2023-02-16 23:33 |
|
Revised |
|
2023-02-27 04:44 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2023-04-17 05:19 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2023-04-17 08:54 |
|
Articles in Press |
|
2023-04-17 08:54 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2023-06-08 01:54 |
|
Publish the Manuscript Online |
|
2023-06-15 06:05 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
5’tiRNA-Pro-TGG, a novel tRNA halve, promotes oncogenesis in sessile serrated lesions and serrated pathway of colorectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xin-Yuan Wang, Yu-Jie Zhou, Hai-Ying Chen, Jin-Nan Chen, Shan-Shan Chen, Hui-Min Chen and Xiao-Bo Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Program of Health and Family Planning Research Project Plan of Pudong New Area Health Committee |
PW2020D-12 |
|
| Corresponding Author |
Xiao-Bo Li, PhD, Chief Doctor, Chief Physician, Professor, Division of Gastroenterology and Hepatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, No. 145 Middle Shandong Road, Shanghai 200000, China. lxb_1969@163.com |
| Key Words |
Noncoding RNA; tRNA halves; Sessile serrated lesions; Colon cancer; Serrated pathway |
| Core Tip |
Our study identified the transfer RNA-derived small RNAs expression profile of sessile serrated lesions (SSLs) for the first time and found that tRNA halves (tiRNAs)-1:33-Pro-TGG-1, which was associated with polyp size, were highly expressed in SSLs and promoted oncogenesis in colorectal cancer cell. Furthermore, tiRNA-1:33-Pro-TGG-1 potentially promotes the progression of serrated pathway colorectal cancer (CRC) through metabolic and immune pathways by interacting with HPSE2 in SSLs and BRAFmut CRC. In the future, tiRNA-1:33-Pro-TGG-1 may serve as a potential target for the early diagnosis of SSLs and treatment of CRC that arises from the serrated pathway. |
| Publish Date |
2023-06-15 06:05 |
| Citation |
Wang XY, Zhou YJ, Chen HY, Chen JN, Chen SS, Chen HM, Li XB. 5’tiRNA-Pro-TGG, a novel tRNA halve, promotes oncogenesis in sessile serrated lesions and serrated pathway of colorectal cancer. World J Gastrointest Oncol 2023; 15(6): 1005-1018 |
| URL |
https://www.wjgnet.com/1948-5204/full/v15/i6/1005.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i6.1005 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
