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2/2/2024 9:42:16 AM | Browse: 82 | Download: 205
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 83737
Country China
Received
2023-10-27 02:18
Peer-Review Started
2023-10-27 02:20
To Make the First Decision
Return for Revision
2023-11-09 12:34
Revised
2023-11-23 07:32
Second Decision
2024-01-09 02:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2024-01-09 04:00
Articles in Press
2024-01-09 04:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
2024-01-08 02:38
Typeset the Manuscript
2024-01-29 01:07
Publish the Manuscript Online
2024-02-02 09:42
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Prohibitin 1 inhibits cell proliferation and induces apoptosis via the p53-mediated mitochondrial pathway in vitro
Manuscript Source Unsolicited Manuscript
All Author List Juan-Juan Shi, Yi-Kai Wang, Mu-Qi Wang, Jiang Deng, Ning Gao, Mei Li, Ya-Ping Li, Xin Zhang, Xiao-Li Jia, Xiong-Tao Liu, Shuang-Suo Dang and Wen-Jun Wang
ORCID
Author(s) ORCID Number
Juan-Juan Shi http://orcid.org/0000-0002-5626-9821
Yi-Kai Wang http://orcid.org/0000-0001-6709-1777
Mu-Qi Wang http://orcid.org/0000-0003-2314-8983
Jiang Deng http://orcid.org/0000-0001-8645-3825
Ning Gao http://orcid.org/0000-0003-1018-3990
Mei Li http://orcid.org/0000-0001-6295-4270
Ya-Ping Li http://orcid.org/0000-0002-0900-5559
Xin Zhang http://orcid.org/0000-0002-5966-0471
Xiao-Li Jia http://orcid.org/0000-0001-8865-9771
Xiong-Tao Liu http://orcid.org/0000-0002-7367-6488
Shuang-Suo Dang http://orcid.org/0000-0003-0918-9535
Wen-Jun Wang http://orcid.org/0000-0001-9861-1763
Funding Agency and Grant Number
Funding Agency Grant Number
the Key Research and Development Program of Shaanxi 2021SF-227
the Natural Science Basic Research Program of Shaanxi 2020SF-297
the Natural Science Basic Research Program of Shaanxi 2023-JC-YB-770
Corresponding Author Wen-Jun Wang, MD, Doctor, Infectious Diseases, the Second Affiliated Hospital of Xi’an Jiaotong University, 157 Xiwu Road, Xincheng District, Xi’an 710004, Shaanxi Province,, Xi'an 710004, Shaannxi Province, China. alargo@163.com
Key Words Prohibitin 1; Hepatocellular carcinoma cells; Apoptosis; Cell cycle; Mitochondrial pathway
Core Tip Prohibitin 1 (PHB1) has been identified as an antiproliferative protein that may play an important role in the progression of hepatocellular carcinoma (HCC). However, the role of PHB1 in HCC is controversial. Here, we investigated the effect of PHB1 on HCC cells and the underlying molecular mechanisms. Our findings demonstrated that PHB1 is a unique tumour suppressor and that its overexpression inhibits human HCC cell viability by arresting the cell cycle and inducing cell apoptosis via activation of the p53-mediated mitochondrial pathway.
Publish Date 2024-02-02 09:42
Citation Shi JJ, Wang YK, Wang MQ, Deng J, Gao N, Li M, Li YP, Zhang X, Jia XL, Liu XT, Dang SS, Wang WJ. Prohibitin 1 inhibits cell proliferation and induces apoptosis via the p53-mediated mitochondrial pathway in vitro. World J Gastrointest Oncol 2024; 16(2): 398-413
URL https://www.wjgnet.com/1948-5204/full/v16/i2/398.htm
DOI https://dx.doi.org/10.4251/wjgo.v16.i2.398
Full Article (PDF) WJGO-16-398-with-cover.pdf
Full Article (Word) WJGO-16-398.docx
Manuscript File 83737_Auto_Edited-CL-WangTQ-YJP.docx
Answering Reviewers 83737-Answering reviewers.pdf
Audio Core Tip 83737-Audio core tip.mp3
Biostatistics Review Certificate 83737-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 83737-Conflict-of-interest statement.pdf
Copyright License Agreement 83737-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 83737-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 83737-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 83737-Language certificate.pdf
Peer-review Report 83737-Peer-review(s).pdf
Scientific Misconduct Check 83737-Bing-Lin C-2.png
Scientific Editor Work List 83737-Scientific editor work list.pdf
CrossCheck Report 83737-CrossCheck.png
CrossCheck Report 83737-CrossCheck report.pdf