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Articles Published Processes
8/10/2023 1:26:04 PM | Browse: 217 | Download: 750
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Received |
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2023-02-09 03:31 |
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Peer-Review Started |
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2023-02-09 03:35 |
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To Make the First Decision |
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Return for Revision |
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2023-05-16 11:42 |
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Revised |
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2023-05-26 10:36 |
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Second Decision |
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2023-07-14 02:43 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-07-17 01:26 |
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Articles in Press |
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2023-07-17 01:26 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-08-03 07:52 |
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Publish the Manuscript Online |
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2023-08-10 13:26 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Exploring the regulatory mechanism of tRNA-derived fragments 36 in acute pancreatitis based on small RNA sequencing and experiments
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xi-Rui Fan, Yun Huang, Yu Su, Si-Jin Chen, Yu-Lu Zhang, Wei-Kang Huang and Hui Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81860424 |
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| Corresponding Author |
Hui Wang, PhD, Doctor, Doctor, Department of Gastroenterology, The Affiliated Yan’an Hospital of Kunming Medical University, Renmin East Road, Panlong District, Kunming 650051, Yunnan Province, China. wanghui@kmmu.edu.cn |
| Key Words |
Acute pancreatitis; tRNA-derived fragments; tRNA-derived fragments 36; Mouse models; Ferroptosis; Reverse transcription quantitative polymerase chain reaction |
| Core Tip |
Based on reverse transcription quantitative polymerase chain reaction and bioinformatic analysis of small RNA sequencing data extracted from three patients and three healthy controls, and validated by 20 acute pancreatitis (AP) patients and 20 healthy controls, we found that tRNA-derived fragments 36 (tRF36) was significantly upregulated in AP. Furthermore, the results of the cell model of the MCP-83 cell line and knockdown of tRF36 suggested that tRF36 contributed to AP progression by promoting cell death. |
| Publish Date |
2023-08-10 13:26 |
| Citation |
Fan XR, Huang Y, Su Y, Chen SJ, Zhang YL, Huang WK, Wang H. Exploring the regulatory mechanism of tRNA-derived fragments 36 in acute pancreatitis based on small RNA sequencing and experiments. World J Gastroenterol 2023; 29(30): 4642-4656 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i30/4642.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i30.4642 |
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