Publication Name	World Journal of Radiology
Manuscript ID	8386
Country	Japan

Received	2013-12-28 11:08
Peer-Review Started	2013-12-28 14:37
To Make the First Decision	2014-02-13 16:24
Return for Revision	2014-02-20 23:01
Revised
Second Decision	2014-05-29 08:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-29 09:34
Articles in Press	2014-05-29 11:00
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-07-08 13:18
Typeset the Manuscript	2014-08-25 09:31
Publish the Manuscript Online	2014-08-28 18:31

ISSN	1949-8470 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Review
Article Title	Incorporating GSA-SPECT into CT-based dose-volume histograms for advanced hepatocellular carcinoma radiotherapy
Manuscript Source	Invited Manuscript
All Author List	Shintaro Shirai, Morio Sato, Yasutaka Noda, Yoshitaka Kumayama and Noritaka Shimizu
Funding Agency and Grant Number
Corresponding Author	Morio Sato, MD, Professor, Department of Radiology, Wakayama Medical University, 811-1 Kimiidera, Wakayama Shi, Wakayama 641-8510, Japan. morisato@mail.wakayama-med.ac.jp
Key Words	Functional image-guided radiotherapy; Galactosyl human serum albumin; Dose-volume histogram; Three-dimensional radiotherapy; Hepatocellular carcinoma
Core Tip	Three-dimensional conformal radiotherapy, which is designed to preserve functional liver, can be visualized by single photon emission computed tomography with Tc-99m-galactosyl human serum albumin (GSA). This treatment modality has promising therapeutic effects for hepatocellular carcinomas (HCCs) of > 14 cm in diameter that are unmanageable by proton beam therapy. A treatment plan designed to irradiate ≤ 20% of the functional liver volume (FLV20Gy ≤ 20%) did not cause radiation-induced liver disease. Therefore, FLV20Gy ≤ 20% may be a useful safety marker for three-dimensional radiotherapy of HCC of various sizes. It is also possible to estimate the effects of radiotherapy on the liver by dividing the GSA count in the region of the liver irradiated with ≥ 20 Gy by the GSA count of the entire liver.
Publish Date	2014-08-28 18:31
Citation	Shirai S, Sato M, Noda Y, Kumayama Y, Shimizu N. Incorporating GSA-SPECT into CT-based dose-volume histograms for advanced hepatocellular carcinoma radiotherapy. World J Radiol 2014; 6(8): 598-606
URL	http://www.wjgnet.com/1949-8470/full/v6/i8/598.htm
DOI	http://dx.doi.org/10.4329/wjr.v6.i8.598

Full Article (PDF)	WJR-6-598.pdf
Full Article (Word)	WJR-6-598.doc
Manuscript File	8386-Review.docx
Answering Reviewers	8386-Answering reviewers.pdf
Copyright License Agreement	8386-Copyright assignment.pdf
Peer-review Report	8386-Peer review(s).pdf
Scientific Misconduct Check	8386-CrossCheck.jpg
Scientific Editor Work List	8386-Scientific editor work list.pdf