| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Mechanism of annexin A1/N-formylpeptide receptor regulation of macrophage function to inhibit hepatic stellate cell activation through Wnt/β-catenin pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun-Hua Fan, Na Luo, Geng-Feng Liu, Xiao-Fang Xu, Shi-Quan Li and Xiao-Ping Lv |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grant-in-Aid for Scientific Research from National Natural Science Foundation of China |
81860120, 81860104 |
| Guangxi Natural Science Foundation |
2017GXNSFBA198134, 2017GXNSFAA198299 |
| Guangxi Natural Science Foundation |
2015GXNSFCA139024 |
|
| Corresponding Author |
Jun-Hua Fan, Doctor, MD, PhD, Associate Professor, Doctor, Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. fanjunhuaxiaoshe@hotmail.com |
| Key Words |
Annexin A1; Active N-terminal peptide of annexin A1; Macrophage; Hepatic stellate cell; Wnt/β-catenin; Liver fibrosis |
| Core Tip |
Hepatic stellate cells (HSCs) are the main receiver of inflammatory signals and the main promoter of fibrosis. Kupffer cells are activated by damage-associated molecular patterns or lipopolysaccharide, and other pathogen-associated molecular patterns, producing and releasing cytokines to activate HSCs, causing secretion and deposition of extracellular matrix and liver fibrosis. Annexin (Anx)A1 is a glucocorticoid regulatory protein that enhances efferocytosis in macrophages, inhibits activation of phospholipase A2, downregulates expression of inflammatory arachidonic acid, and negatively regulates inflammatory cells and factors. Whether AnxA1 is involved in the formation of liver fibrosis and its mechanism of action were the focus of this study. |
| Publish Date |
2023-06-07 06:39 |
| Citation |
Fan JH, Luo N, Liu GF, Xu XF, Li SQ, Lv XP. Mechanism of annexin A1/N-formylpeptide receptor regulation of macrophage function to inhibit hepatic stellate cell activation through Wnt/β-catenin pathway. World J Gastroenterol 2023; 29(22): 3422-3439 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i22/3422.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i22.3422 |
