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Articles Published Processes
7/13/2023 8:03:56 AM | Browse: 222 | Download: 607
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Received |
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2023-02-16 09:27 |
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Peer-Review Started |
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2023-02-16 09:29 |
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To Make the First Decision |
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Return for Revision |
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2023-04-11 06:39 |
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Revised |
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2023-05-12 08:59 |
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Second Decision |
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2023-05-22 03:16 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-05-22 09:20 |
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Articles in Press |
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2023-05-22 09:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-07-05 11:58 |
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Publish the Manuscript Online |
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2023-07-13 08:03 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Ophthalmology |
| Manuscript Type |
Review |
| Article Title |
Klotho: A new therapeutic target in diabetic retinopathy?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Alessandra Puddu and Davide Carlo Maggi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Alessandra Puddu, BSc, Technician, Department of Internal Medicine and Medical Specialties, University of Genova, Viale Benedetto XV 6, Genova 16132, Italy. alep100@hotmail.com |
| Key Words |
Klotho; Diabetic retinopathy; Retinal pigment epithelium; Vascular endothelial growth factor A; Epithelial to mesenchimal transition; Ocular neovascularization |
| Core Tip |
In diabetic Patients, serum levels of Klotho (Kl) are significantly decreased compared to healthy subjects. Moreover, serum Kl levels are negatively correlated with worsening of diabetic retinopathy (DR). Several evidence suggests that retina homeostasis may be affected by altered expression of membrane Kl, as well by reduced levels of soluble Kl. In this review we focused on the role of Kl in DR, highlighting the importance of Kl in maintaining retinal homeostasis and its positive effects on several mechanisms involved in DR onset and progression. Therefore, Kl could be a novel biomarker and a good candidate for the treatment of DR. |
| Publish Date |
2023-07-13 08:03 |
| Citation |
Puddu A, Maggi DC. Klotho: A new therapeutic target in diabetic retinopathy? World J Diabetes 2023; 14(7): 1027-1036 |
| URL |
https://www.wjgnet.com/1948-9358/full/v14/i7/1027.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i7.1027 |
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