Publication Name	World Journal of Cardiology
Manuscript ID	8398
Country	Germany

Received	2013-12-28 11:41
Peer-Review Started	2013-12-28 15:26
To Make the First Decision	2014-01-15 16:27
Return for Revision	2014-01-20 14:57
Revised	2014-01-26 20:31
Second Decision	2014-05-29 16:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-29 17:03
Articles in Press	2014-05-29 17:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-17 13:58
Publish the Manuscript Online	2014-08-20 20:27

ISSN	1949-8462 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Calpain system and its involvement in myocardial ischemia and reperfusion injury
Manuscript Source	Invited Manuscript
All Author List	Christiane Neuhof and Heinz Neuhof
Funding Agency and Grant Number
Corresponding Author	Christiane Neuhof, MD, Department of Internal Medicine I, Cardiology, Justus-Liebig-University of Giessen, Klinikstrasse 33, 35392 Giessen, Germany. christiane.neuhof@innere.med.uni-giessen.de
Key Words	Calpain; Calpain inhibition; Calcium overload; Myocardial injury; Ischemia; Reperfusion; Myocardial infarction; Remodelling
Core Tip	Calpains, calcium-dependant cytosolic cysteine proteases, are essentially involved in the pathophysiology of myocardial infarction. Their inhibition has shown in animal experiments an enhanced tolerance towards ischemia, a reduction of myocardial infarction and reperfusion injury, and an improvement of the process of remodelling. The availability of specific calpain inhibitors offers new prophylactic and therapeutic possibilities for patients with myocardial infarction, revascularisation and coronary surgery.
Publish Date	2014-08-20 20:27
Citation	Neuhof C, Neuhof H. Calpain system and its involvement in myocardial ischemia and reperfusion injury. World J Cardiol 2014; 6(7): 638-652
URL	http://www.wjgnet.com/1949-8462/full/v6/i7/638.htm
DOI	http://dx.doi.org/10.4330/wjc.v6.i7.638

Full Article (PDF)	WJC-6-638.pdf
Full Article (Word)	WJC-6-638.doc
Manuscript File	8398-Review.doc
Answering Reviewers	8398-Answering reviewers.pdf
Copyright License Agreement	8398-Copyright assignment.pdf
Peer-review Report	8398-Peer review(s).pdf
Scientific Misconduct Check	8398-CrossCheck.jpg
Scientific Editor Work List	8398-Scientific editor work list.pdf