| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Difference and clinical value of metabolites in plasma and feces of patients with alcohol-related liver cirrhosis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Fan Xu, Yan-Xu Hao, Lei Ma, Meng-Han Zhang, Xuan-Xuan Niu, Yan Li, Yuan-Yuan Zhang, Ting-Ting Liu, Ming Han, Xiao-Xue Yuan, Gang Wan and Hui-Chun Xing |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key R&D Program of China |
2021YFC2301801 |
| Capital's Funds for Health Improvement and Research of China |
2020-1-2171 |
|
| Corresponding Author |
Hui-Chun Xing, Doctor, MD, Chief Doctor, Professor, Center of Liver Diseases Division 3, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing 100015, China. huichunxing@126.com |
| Key Words |
Alcohol-related liver cirrhosis; Plasma; Feces; Metabolites; Deoxycholic acid; Amino acids |
| Core Tip |
Metabolites in enterohepatic circulation play an important role in cross-talk between liver and gut. More than 300 common metabolites were identified in the plasma and feces of patients with alcohol-related liver cirrhosis (ALC) by liquid chromatography-mass spectrometry. And we found bile acid and amino acid were distributed differently in plasma and feces. More importantly, increased glycocholic acid, taurocholic acid, L-phenylalanine, L-tyrosine, and L-methionine in plasma and decreased deoxycholic acid in feces of patients with ALC were related to the severity of ALC. These metabolites have the potential to evaluate the progression of ALC. |
| Publish Date |
2023-06-07 06:39 |
| Citation |
Xu YF, Hao YX, Ma L, Zhang MH, Niu XX, Li Y, Zhang YY, Liu TT, Han M, Yuan XX, Wan G, Xing HC. Difference and clinical value of metabolites in plasma and feces of patients with alcohol-related liver cirrhosis. World J Gastroenterol 2023; 29(22): 3534-3547 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i22/3534.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i22.3534 |
