| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Obstetrics & Gynecology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Cellular and molecular overview of gestational diabetes mellitus: Is it predictable and preventable?
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Pei-Qi Lim, Yen-Ju Lai, Pei-Ying Ling and Kuo-Hu Chen |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Kuo-Hu Chen, MD, MSc, PhD, Academic Editor, Attending Doctor, Chief Physician, Director, Director, Professor, Senior Editor, Senior Researcher, Surgical Oncologist, Teacher, Department of Obstetrics and Gynecology, Taipei Tzu-Chi General Hospital, No. 289 Jianguo Road, 231 Xindian, New Taipei City, Taipei 231, Taiwan. alexgfctw@yahoo.com.tw |
| Key Words |
Gestational diabetes mellitus; Overt diabetes mellitus; Insulin resistance; Diabetes mellitus |
| Core Tip |
Maternal and fetal effects of uncontrolled gestational diabetes mellitus (GDM) include stillbirth, macrosomia, neonatal diabetes, and birth trauma. Risk factors are maternal obesity or overweight, pre-existing diabetes mellitus, and polycystic ovary syndrome. The complex pathophysiology involves genetic variants, pancreatic β cell depletion or dysfunction, aggravated insulin resistance due to glucose transporter 4 translocation failure, and chronic, low-grade inflammation. Antepartum measurements including adipokines (leptin), body mass ratio (waist circumference and waist-to-hip ratio), and biomarkers (microRNA in extracellular vesicles) are useful markers for predicting GDM. For preventing GDM, physical activity and diet (such as the Mediterranean diet) control are effective interventions. |
| Publish Date |
2023-11-14 06:13 |
| Citation |
Lim PQ, Lai YJ, Ling PY, Chen KH. Cellular and molecular overview of gestational diabetes mellitus: Is it predictable and preventable? World J Diabetes 2023; 14(11): 1693-1709 |
| URL |
https://www.wjgnet.com/1948-9358/full/v14/i11/1693.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i11.1693 |
