Publication Name	World Journal of Diabetes
Manuscript ID	8414
Country	Japan

Received	2013-12-28 12:54
Peer-Review Started	2013-12-28 16:48
First Decision by Editorial Office Director
Return for Revision	2014-02-20 23:02
Revised	2014-03-01 01:23
Publication Fee Transferred
Second Decision by Editor	2014-06-03 16:20
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-06-03 16:34
Articles in Press	2014-06-03 16:50
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-05 18:41
Publish the Manuscript Online	2014-08-17 13:16

ISSN	1948-9358 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Hepatocyte growth factor, a biomarker of macroangiopathy in diabetes mellitus
Manuscript Source	Invited Manuscript
All Author List	Hiroyuki Konya, Masayuki Miuchi, Kahori Satani, Satoshi Matsutani, Taku Tsunoda, Yuzo Yano, Tomoyuki Katsuno, Tomoya Hamaguchi, Jun-Ichiro Miyagawa and Mitsuyoshi Namba
Funding Agency and Grant Number
Corresponding Author	Hiroyuki Konya, MD, PhD, Department of Internal Medicine, Ashiya Municipal Hospital, 39-1, Asahigaoka-cho, Ashiya, Hyogo 659-8502, Japan. h-dyer@mvi.biglobe.ne.jp
Key Words	Hepatocyte growth factor; Diabetes mellitus; Carotid atherosclerosis; Macroangiopathy; Biomarker
Core Tip	Hepatocyte growth factor (HGF) has been a mesenchymal-derived polyphenic factor which modulates development, motion, and morphosis of diverse cells, and has been regarded as a humor intermediator of epithelial-mesenchymal interplays. The serum levels of HGF in diabetes mellitus (DM) subjects might be assayed by balancing of stimulators (hypertension, atheromatous arteriosclerosis, etc.) and suppressors (hyperglycemia, transforming growth factor-, angiotensin II, etc.). The elevated serum level of HGF might have been regarded as an indicator of the DM involvements seriousness. Accordingly, the concentration of serum HGF might be a new and meaningful biomarker of macroangiopathy in DM subjects.
Publish Date	2014-08-17 13:16
Citation	Konya H, Miuchi M, Satani K, Matsutani S, Tsunoda T, Yano Y, Katsuno T, Hamaguchi T, Miyagawa JI, Namba M. Hepatocyte growth factor, a biomarker of macroangiopathy in diabetes mellitus. World J Diabetes 2014; 5(5): 678-688
URL	http://www.wjgnet.com/1948-9358/full/v5/i5/678.htm
DOI	http://dx.doi.org/10.4239/wjd.v5.i5.678

Full Article (PDF)	WJD-5-678.pdf
Full Article (Word)	WJD-5-678.doc
Manuscript File	8414-Review.docx
Answering Reviewers	8414-Answering reviewers.pdf
Copyright License Agreement	8414-Copyright assignment.pdf
Peer-review Report	8414-Peer review(s).pdf
Scientific Misconduct Check	8414-CrossCheck.jpg
Scientific Editor Work List	8414-Scientific editor work list.pdf